Microdialysis technique as a monitoring system for acute complications of diabetes

Artificial Organs
Anna CiechanowskaJerzy Kawiak

Abstract

The objective of the study was to establish the quasi-continuous courses, using microdialysis technique, of glucose, lactate, and glycerol concentrations in interstitial fluid of abdominal adipose tissue during the standard treatment of acute diabetes complications. Clinical studies were carried out on 31 diabetic patients during the initial 48 h of the treatment. In all but two obese female patients with hyperglycemic hyperosmolar state (HHS) did glucose concentration in perfusion fluid (PF) reflect concentration in capillary blood. The recovery of glucose correlated with patients' body mass index (r = 0.55). It was significantly higher in lean and overweight patients (91 +/- 15%) than in obese patients (55 +/- 31%). The course of lactate concentration in PF coincided with the course in venous blood (2.1 +/- 0.3 mmol/L vs. 2.0 +/- 0.5 mmol/L, P = 0.35). Glycerol concentration was 267 +/- 41 micromol/L and 133 +/- 40 micromol/L in PF and venous blood, respectively (P = 0.004). The study indicated that microdialysis may be an effective tool to monitor concentration of different metabolites in interstitial fluid of the adipose tissue during treatment of the acute complications of diabetes. Applicability of the technique in the mo...Continue Reading

References

Oct 1, 1991·Journal of Internal Medicine·U Ungerstedt
Feb 24, 2001·Diabetes Care·A E KitabchiB M Wall
Mar 9, 2002·BMJ : British Medical Journal·Markus Müller
May 23, 2002·Current Pharmaceutical Biotechnology·M StahlV Pay
Sep 27, 2003·Diabetes Technology & Therapeutics·Adelbert J M Schoonen, Klaas Jan C Wientjes
May 13, 2004·Postgraduate Medical Journal·P English, G Williams

❮ Previous
Next ❯

Citations

Feb 28, 2009·Artificial Organs·Paul S Malchesky

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Related Papers

The Journal of Emergency Medicine
Rajan AroraNirupama Kannikeswaran
Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Samar K BhowmickKenneth R Rettig
Journal of Critical Care
G E Umpierrez, Amado X Freire
© 2021 Meta ULC. All rights reserved