Microdissection testicular sperm extraction and IVF-ICSI outcome in nonobstructive azoospermia

Andrologia
P RavizziniR Abdelmassih

Abstract

We evaluated the efficiency of microdissection testicular sperm extraction (MicroTESE) in patients with nonobstructive azoospermia (NOA) and their pregnancy outcomes in a programme based on in vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI). Fifty-six MicroTESE procedures were performed in 53 patients with NOA. Pre-operative levels of luteinising hormone, follicle-stimulating hormone (FSH), testosterone and prolactin were obtained and a Doppler sonography examination was conducted. Sperm retrieval rate, mean age of female partner, mean ICSI and fertilisation rate, number and quality of embryos transferred, implantation, pregnancy and miscarriage rates were calculated. Samples for testicular histological analysis were taken trans-operatively in every case. Sperm retrieval rate, mean ICSI per case and fertilisation rate were 57.1%, 7.4% and 58.4% respectively. A significant difference in pre-operative testicular volume (P = 0.001), serum FSH (P = 0.008) and total testosterone levels (P = 0.021) was found in patients from whom sperm could be retrieved. Mean 1.9 type A embryos were transferred per cycle. Implantation, clinical pregnancy and miscarriage rates were 20%, 40% and 18.7% respectively. It is concluded th...Continue Reading

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Citations

Jul 21, 2014·Human Reproduction Update·Francesco Lotti, Mario Maggi
Nov 30, 2013·The Urologic Clinics of North America·James M Hotaling, Zamip Patel
Jun 21, 2011·The Journal of Urology·John W WeedinLarry I Lipshultz
Dec 3, 2014·The Journal of Urology·Suzanne R GudemanDonald Crain
Aug 6, 2013·The Journal of Urology·Campbell F BrysonPeter N Schlegel
May 14, 2016·BMC Urology·Giorgio FrancoErmanno Greco
Sep 13, 2014·Urologia·Giorgio FrancoCarlo De Dominicis
Apr 28, 2018·Journal of Assisted Reproduction and Genetics·Jennifer F KawwassDmitry M Kissin
Aug 31, 2018·Andrologia·Anne-Laure BarbotinValerie Mitchell
Oct 31, 2019·Human Reproduction Update·Giovanni CoronaNikolaos Sofikitis
Jan 28, 2021·Journal of Clinical Medicine·Ettore Caroppo, Giovanni M Colpi
Apr 3, 2021·The Journal of International Medical Research·Lin QiYing C Su
Apr 4, 2021·Journal of Clinical Medicine·Caroline KangPeter N Schlegel

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