Microdomain-specific localization of functional ion channels in cardiomyocytes: an emerging concept of local regulation and remodelling

Biophysics Reviews
Marina BalychevaJulia Gorelik

Abstract

Cardiac excitation involves the generation of action potential by individual cells and the subsequent conduction of the action potential from cell to cell through intercellular gap junctions. Excitation of the cellular membrane results in opening of the voltage-gated L-type calcium ion (Ca(2+)) channels, thereby allowing a small amount of Ca(2+) to enter the cell, which in turn triggers the release of a much greater amount of Ca(2+) from the sarcoplasmic reticulum, the intracellular Ca(2+) store, and gives rise to the systolic Ca(2+) transient and contraction. These processes are highly regulated by the autonomic nervous system, which ensures the acute and reliable contractile function of the heart and the short-term modulation of this function upon changes in heart rate or workload. It has recently become evident that discrete clusters of different ion channels and regulatory receptors are present in the sarcolemma, where they form an interacting network and work together as a part of a macro-molecular signalling complex which in turn allows the specificity, reliability and accuracy of the autonomic modulation of the excitation-contraction processes by a variety of neurohormonal pathways. Disruption in subcellular targeting of...Continue Reading

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Citations

Feb 28, 2020·Biochemical Society Transactions·Aleksandra JudinaPeter T Wright
Dec 15, 2019·Acta Physiologica·Xiao-Xin JiangDai-Min Zhang
Jan 7, 2019·Pflügers Archiv : European journal of physiology·Robert MallmannLubica Lacinova
Sep 1, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Sinai LiQian Lin
Dec 20, 2020·Biomedicines·Mudit Mishra, Bart De Geest

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