Microdose lithium reduces cellular senescence in human astrocytes - a potential pharmacotherapy for COVID-19?

Aging
Tania Araujo VielJulie K Andersen

Abstract

Cell senescence is a process that causes growth arrest and the release of a senescence associated secretory phenotype (SASP), characterized by secretion of chemokines, cytokines, cell growth factors and metalloproteases, leading to a tissue condition that may precipitate cancers and neurodegenerative processes. With the recent pandemic of coronavirus, senolytic drugs are being considered as possible therapeutic tools to reduce the virulence of SARS-CoV-2. In the last few years, our research group showed that lithium carbonate at microdose levels was able to stabilize memory and change neuropathological characteristics of Alzheimer's disease (AD). In the present work, we present evidence that low-dose lithium can reduce the SASP of human iPSCs-derived astrocytes following acute treatment, suggesting that microdose lithium could protect cells from senescence and development of aging-related conditions. With the present findings, a perspective of the potential use of low-dose lithium in old patients from the "high risk group" for COVID-19 (with hypertension, diabetes and chronic obstructive pulmonary disease) is presented.

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Citations

Nov 14, 2020·Reviews in the Neurosciences·Milena de Barros VianaGlauce Socorro de Barros Viana
Apr 4, 2021·Biology·Graciela Gavia-GarcíaVíctor Manuel Mendoza-Núñez
May 24, 2021·Cancer Treatment and Research Communications·Md Mohiuddin, Kazuo Kasahara
Sep 10, 2021·Frontiers in Aging Neuroscience·Helena Nascimento MalerbaTania Araujo Viel

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Methods Mentioned

BETA
ELISA
electrophoresis

Software Mentioned

Graph Pad Prism
GraphPad

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