Microdosimetric considerations for radiation response studies using Raman spectroscopy

Medical Physics
P A K Oliver, Rowan M Thomson

Abstract

Recent Raman spectroscopy (RS) studies of radiation response involve subcellular (μm-scale) sampling volumes and macroscopic doses as low as 0.005 Gy. These studies ignore the stochastic nature of radiation transport and energy deposition, which can lead to considerable microdosimetric "spread" (i.e., variation in energy deposition). The goal of this work is to use Monte Carlo (MC) simulations to investigate the microdosimetric spread across populations of microscopic targets relevant for RS studies of cellular radiation response. Simulation geometries involve populations of 1600 cells, with two sizes of sampling volumes (representative of recent RS studies) considered within each nucleus, as well as averaging over multiple sampling volumes in the same nucleus. To investigate variation in microdosimetric spread as a function of dose and target size, simple cubic voxel geometries are also considered. MC simulations are used to score energy imparted per unit mass (specific energy, z) in targets (nuclei, sampling volumes, and voxels), considering doses from a few mGy to several Gy. Three photon spectra are considered: 120 kVp x-ray, cobalt-60, and a 6 MV medical linac. For μm-sized targets, there can be considerable variation in e...Continue Reading

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Jun 28, 2018·Physics in Medicine and Biology·P A K Oliver, Rowan M Thomson

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Citations

Nov 1, 2020·Medical Physics·Rodrigo Hernández MillaresSung-Joon Ye

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