Microdroplet dissolution into a second-phase solvent using a micropipet technique: test of the Epstein-Plesset model for an aniline-water system

Langmuir : the ACS Journal of Surfaces and Colloids
P Brent Duncan, David Needham

Abstract

The Epstein-Plesset model was originally derived for the dissolution of a single gas bubble in an infinite aqueous solution (Epstein, P. S.; Plesset, M. S. J. Chem. Phys. 1950, 18, 1505-1509). The micropipet manipulation technique was previously shown to test this theory on air microbubbles and air-filled lipid-coated microparticles accurately and appropriately (Duncan, P. B.; Needham, D. Langmuir 2004, 20, 2567-2578). This same theory is now tested to model liquid microdroplet dissolution in a well-defined solution environment. As presented previously for the gas-bubble system, holding a single microparticle at the end of a micropipet was not shown to affect the dissolution profile and allowed isotropic diffusion significantly, a necessary condition for the validation of the theory. Here, an aniline-water system with an initial droplet diameter of 50 microm was used as a model liquid-liquid system. A microdroplet of aniline in an aqueous solution presatureated with aniline at distinct levels was tested, as was the reverse system of a water droplet in an aniline solution. The dissolution lifetime was shown to increase with increasing medium saturation fraction according to the Epstein-Plesset time-dependent theory (including th...Continue Reading

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Citations

Apr 10, 2012·Molecular Pharmaceutics·Samuel E GilchristHelen M Burt
Feb 27, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Takaichi WatanabeJoão T Cabral
Jan 15, 2014·Journal of Pharmaceutical Sciences· AniketDavid Needham
Dec 17, 2009·Journal of Colloid and Interface Science·Amit Katiyar, Kausik Sarkar
Mar 23, 2010·Biophysical Journal·Deborah L RickardDavid Needham
Apr 17, 2015·Faraday Discussions·Zoubida HammadiStéphane Veesler
Nov 11, 2014·Soft Matter·J M Solano-AltamiranoSaul Goldman
Nov 28, 2014·Lab on a Chip·Marie LemanPatrick Tabeling
Jul 28, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Christiana E UdohJoão T Cabral
Aug 30, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Adil MustafaAlper Kiraz
Sep 21, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Jonathan T Su, David Needham
Sep 28, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Isaac Rodríguez-RuizStéphane Veesler
Sep 15, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Yuting SongXuehua Zhang
Nov 2, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Deborah L BitterfieldDavid Needham
Sep 21, 2016·Journal of Drug Targeting·David NeedhamPrasad Walke
Dec 14, 2016·Journal of Pharmaceutical Sciences·Elisa ParraDavid Needham
May 1, 2020·Soft Matter·José M Encarnación EscobarDetlef Lohse
Feb 18, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Sunghee LeeAileen G Hilario
Nov 15, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Amy Q ShenPatrick T Spicer
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Charlotte A HenshawPhilip M Williams
Oct 6, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Andrea Lamorgese, Roberto Mauri
Apr 21, 2020·ACS Omega·Chia-Yu Chen, Kyriakos D Papadopoulos
Oct 11, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Yong-Jun ChenKenichi Yoshikawa
Mar 7, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Anders UtoftDavid Needham
Sep 22, 2021·International Journal of Pharmaceutics·Ashutosh SharmaHelen Hughes

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