Microdynamics of the piezo-driven pipettes in ICSI

IEEE Transactions on Bio-medical Engineering
Kerem Ediz, Nejat Olgac

Abstract

Undesirably low success rates have been reported in the intracytoplasmic sperm injection procedure. Recently a method using piezo-driven pipettes with a very small mercury column contributed substantial improvements in this process. Despite the toxicity of mercury, this new procedure is commonly utilized in many laboratories. However, there is no study available to date on the micromechanics of this procedure. The underlying principles of piercing are not clear for both cases, with and without the mercury. Presently, the pressure burst, which is caused by the abrupt axial motion of the mercury column, is attributed to this effect. Here, we take the mercury-filled pipettes and try to understand the governing physics. The findings point out the occurrence of considerable lateral tip oscillations of the injection pipette as the piezoelectric pulse train is introduced. We claim that the lateral dynamics play an important role in the piercing and should be considered to enlighten the process and the effects of the mercury. These claims are analytically studied and experimentally verified.

References

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Citations

May 17, 2011·Biomedical Microdevices·Haibo HuangDong Sun
Aug 3, 2005·Journal of Biomechanical Engineering·Kerem Ediz, Nejat Olgac
Dec 15, 2010·Journal of Biomechanical Engineering·Jhon F DiazAli Fuat Ergenc
Jun 15, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Sumio Ishijima
Jun 2, 2014·The Review of Scientific Instruments·Zhi Sen DengZhi Hua Feng
Oct 19, 2006·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·Ali Fuat Ergenc, Nejat Olgac
Sep 1, 2010·The International Journal of Robotics Research·D Caleb RuckerNoah J Cowan
Jun 11, 2017·IEEE Transactions on Bio-medical Engineering·Wesley JohnsonYu Sun
Apr 26, 2008·Molecular Reproduction and Development·Ali Fuat ErgencNejat Olgac
Dec 19, 2008·Biology of Reproduction·Ryuzo Yanagimachi
Dec 21, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Mehdi Karzar-JeddiTai-Hsi Fan
Aug 21, 2019·Biomedical Microdevices·Handan Nak, Ali Fuat Ergenc
Jan 1, 2013·Journal of Medical Engineering·Zhenyu Zhang, Nejat Olgac

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