Microecology, bacterial vaginosis and probiotics: perspectives for bacteriotherapy

Medical Hypotheses
G FamularoC De Simone

Abstract

Probiotics enriched in lactobacilli have been proposed as an effective and alternative tool to antibiotics for the treatment of bacterial vaginosis. The protective role of H(2)O(2)-producing lactobacilli has been strongly emphasized, but no clear-cut correlation appears to link the metabolic characteristics of administered lactobacilli with the clinical impact of probiotic therapy. On account of our review of basic mechanisms involved in bacterial vaginosis, we suggest that lactobacilli with an elevated arginine deiminase activity could have a greater therapeutic potential than strains producing only H(2)O(2). Preliminary results from our laboratory have demonstrated that treatment with probiotics containing arginine deiminase-positive lactobacilli improves clinical symptoms and is paralleled by a significant decline of polyamine levels in vaginal microenvironment. This is of outstanding interest due to the central role of polyamines in the pathogenesis of bacterial vaginosis. We should critically rethink, against this perspective, the use of probiotics for the treatment of affected women.

References

May 1, 1979·The Journal of Clinical Investigation·K C ChenK K Holmes
May 1, 1992·Sexually Transmitted Diseases·A HallénC Påhlson
Oct 1, 1991·Medical Hypotheses·C Påhlson, P G Larsson
Sep 1, 1990·Reviews of Infectious Diseases·V Redondo-LopezJ D Sobel
Apr 1, 1988·American Journal of Obstetrics and Gynecology·D A EschenbachK K Holmes
Dec 1, 1985·American Journal of Obstetrics and Gynecology·J R WoodM Robbie
Aug 1, 1985·The Journal of Infectious Diseases·K K HolmesD A Eschenbach
Oct 1, 1982·European Journal of Clinical Microbiology·J C Clay
Aug 1, 1994·Acta Obstetricia Et Gynecologica Scandinavica·J J Platz-ChristensenP G Larsson
Aug 1, 1993·American Journal of Obstetrics and Gynecology·G B Hill
Jan 1, 1993·Acta Obstetricia Et Gynecologica Scandinavica·A NeriZ Samra
Jul 1, 1997·Obstetrics and Gynecology·P NyirjesyB Lorber
Dec 20, 1997·The New England Journal of Medicine·J D Sobel
Sep 2, 1998·Annals of Periodontology·G B Hill
Sep 2, 1998·Molecular Microbiology·A SekowskaA Danchin
Nov 25, 1998·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·N E OsmanB Karlsson
Jul 16, 1999·Biochemical and Biophysical Research Communications·H GongL Schweigerer
Jul 27, 1999·Journal of Acquired Immune Deficiency Syndromes : JAIDS·L Al-HarthiG T Spear
Aug 24, 1999·American Journal of Obstetrics and Gynecology·A G RodriguesA F da Fonseca
Jan 1, 1995·Infectious Diseases in Obstetrics and Gynecology·M A Oleen-Burkey, S L Hillier

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Citations

Aug 29, 2013·BioMed Research International·Baljinder KaurNeena Garg
May 31, 2003·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Heather S Jeavons
Jul 16, 2011·Trends in Endocrinology and Metabolism : TEM·Bryan A WhiteBrenda A Wilson
Jan 24, 2014·Journal of the Science of Food and Agriculture·Jeong-Eun ParkYoun-Soo Cha
Oct 31, 2003·American Journal of Obstetrics and Gynecology·Gregor Reid, Alan Bocking
Jun 5, 2002·Clinical Reviews in Allergy & Immunology·John BienenstockPaul Keith
Oct 12, 2010·Analytical and Bioanalytical Chemistry·Elisabetta GiorginiOliana Carnevali
Oct 4, 2012·FEMS Microbiology Reviews·Elizabeth Carmel Murphy, Inga-Maria Frick
Aug 15, 2014·International Journal of Oncology·Michele LinsalataFrancesco Russo
Oct 14, 2014·World Journal of Gastroenterology : WJG·Francesco RussoAntonella Orlando
Nov 28, 2007·Nutrition Reviews·Irene Lenoir-WijnkoopDanielle A W Wolvers
Apr 1, 2021·Scientific Reports·Maximilien ClabautMarc G J Feuilloley

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