Microelectrode investigation of neuroneal ageing from a single identified neurone

Physical Chemistry Chemical Physics : PCCP
Bhavik Anil PatelDanny O'Hare

Abstract

Microelectrode amperometry is uniquely suited for characterising the dynamics of neurotransmitter release, as it offers unparalleled spatial and temporal resolution. We have used carbon fibre microelectrodes to study release of the monoamine neurotransmitter serotonin (5-HT) and the gaseous transmitter nitric oxide (NO) in intact central nervous system of the water snail, Lymnaea stagnalis. Analysis of spontaneous vesicular release of 5-HT and depolarisation-induced release of NO reveals significant differences with ageing that may be associated with changes in protein structure and function.

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Citations

Apr 20, 2011·Analytical Chemistry·Yuqing LinAndrew G Ewing
May 23, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Zsolt PirgerIldikó Kemenes
Jan 17, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·István FodorZsolt Pirger
Apr 3, 2013·Analytical Chemistry·Raphaël Trouillon, Andrew G Ewing

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