Microemulsified cyclosporine-based immunosuppression for the prevention of acute renal allograft rejection in unrelated dogs: preliminary experimental study

Veterinary Surgery : VS
Lynda BernsteenJohn Patz

Abstract

To determine whether the microemulsified formulation of cyclosporine (MCsA; Neoral; Novartis A.G.), combined with azathioprine (Imuran; Glaxo Wellcome), and prednisolone (Delta-Cortef; Upjohn), would be effective in preventing acute renal allograft rejection in unrelated mongrel dogs. To document any toxic effects associated with this drug combination. rospective, pilot study. Four healthy, adult, mongrel, canine renal allograft recipients. Heterotopic renal transplantation, with bilateral nephrectomy, was performed in 4 dogs. Allografts were harvested from 2 unrelated dogs that were to be euthanatized for reasons unrelated to this study. The dogs were treated for 100 days or until signs of illness or allograft rejection required euthanasia. Microemulsified cyclosporine (20 mg/kg/day), azathioprine (5 mg/kg every other day), and prednisolone (1 mg/kg/day) were administered for the prevention of acute rejection. Body weight, serum biochemistry profiles, complete blood counts, and trough whole-blood cyclosporine concentrations were measured throughout the study. Cyclosporine dose was adjusted to maintain a trough concentration of 400-500 ng/mL. Azathioprine dose was decreased if evidence of hepatotoxicity developed or if the tota...Continue Reading

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Citations

Jan 20, 2012·Journal of the American Veterinary Medical Association·Heidi Phillips, Lillian R Aronson
Oct 31, 2008·Australian Veterinary Journal·C G Baxter, L J Vogelnest
Feb 14, 2006·Veterinary Surgery : VS·Chad SchmiedtJonathan McAnulty
Feb 14, 2006·Veterinary Surgery : VS·Kristyn D BroaddusClinton D Lothrop
Feb 14, 2006·Veterinary Surgery : VS·Clare R GregoryMargo Mehl
Apr 1, 2006·The Journal of Small Animal Practice·K Gnirs
Jan 14, 2012·Veterinary Surgery : VS·Kate HopperClare R Gregory
Dec 18, 2013·Journal of Veterinary Internal Medicine·T M ArcherA J Mackin
Mar 1, 2012·The Veterinary Journal·C Underwood, A W van Eps
Jun 24, 2016·Journal of Chromatographic Science·Georgeta-Simona StanHassan Y Aboul-Enein
Jul 12, 2013·The Journal of Veterinary Medical Science·Kyung-Mee ParkHeung-Myong Woo

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