Microemulsion system with improved loading of piroxicam: a study of microstructure

AAPS PharmSciTech
Muhammad Faizan NazarSyed Sakhawat Shah

Abstract

Formulation of a new oil-in-water (o/w) microemulsion composed of castor oil/Tween 80/ethanol/phosphate buffer for enhancing the loading capacity of an anti-inflammatory drug piroxicam has been accomplished. The pseudo-ternary phase diagram has been delineated at constant surfactant/cosurfactant ratio (1:2). The internal structure of so created four-component system was elucidated by means of an analysis of isotropic area magnitudes in the phase diagram. Conductivity (sigma), kinematic viscosity (keta), and surface tension (gamma) studies with the variation in Phiw (weight fraction of aqueous phase) show the occurrence of structural changes from water-in-oil (w/o) microemulsion to oil-in-water (o/w). Along with the solubility and partition studies of piroxicam in microemulsion components, the changes in the microstructure of the microemulsion after incorporation of drug have been evaluated using pH, sigma, gamma, keta, and density studies. Piroxicam, a poorly water-soluble drug displayed high solubility (1.0%) in an optimum microemulsion formulation using ethanol (55.0%), Tween 80 (26.5%), castor oil (7.5%), and phosphate buffer (11.0%). The results have shown that the microemulsion remained stable after the incorporation of pi...Continue Reading

References

Aug 4, 1998·Journal of Pharmaceutical Sciences·S HenryM R Prausnitz
Oct 28, 1998·Methods and Findings in Experimental and Clinical Pharmacology·W A Ritschel, S S Bharaj
Apr 1, 1986·Physical Review A: General Physics·G S GrestA L Bug
Mar 4, 2000·International Journal of Pharmaceutics·R G AlanyI G Tucker
Dec 6, 2000·Advanced Drug Delivery Reviews·M J Lawrence, G D Rees
Mar 16, 2001·International Journal of Pharmaceutics·J Y FangY H Tsai
Mar 8, 2003·International Journal of Pharmaceutics·S PeltolaA Urtti
May 8, 2004·International Journal of Pharmaceutics·Ljiljana DjordjevicDanina Krajisnik
Mar 26, 2005·Archives of Pharmacal Research·Eun-Seok ParkSang-Cheol Chi
Jun 22, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·K KrauelT Rades
Aug 2, 2005·Journal of Colloid and Interface Science·J Dasilva-CarbalhalM Pérez-Lorenzo
Jul 18, 2006·Advances in Colloid and Interface Science·Anna Kogan, Nissim Garti
Aug 1, 2006·International Journal of Pharmaceutics·Yue YuanDa-fang Zhong
Jan 19, 2007·Advances in Colloid and Interface Science·Aviram Spernath, Abraham Aserin
Jul 25, 2007·Colloids and Surfaces. B, Biointerfaces·S K MehtaK K Bhasin
Feb 26, 2008·International Journal of Pharmaceutics·Abhijit A Date, M S Nagarsenker
Mar 11, 2008·Journal of Colloid and Interface Science·Katarzyna ZielińskaTeofil Jesionowski

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Citations

May 8, 2004·International Journal of Pharmaceutics·Ljiljana DjordjevicDanina Krajisnik
Jul 19, 2014·International Journal of Pharmaceutics·Abdelkader MouriPhilippe Legrand
Jul 24, 2015·Drug Development and Industrial Pharmacy·Anna FroelichWojciech Białas
Jun 6, 2012·Expert Opinion on Drug Delivery·Stéphane Gibaud, David Attivi
Nov 22, 2013·Journal of Pharmaceutical Sciences·Heike FriedlAndreas Bernkop-Schnürch
Dec 31, 2015·The Journal of Pharmacy and Pharmacology·Arunprasad Sivaraman, Ajay K Banga
Jan 1, 2014·International Scholarly Research Notices·Sajal Kumar JhaD Harinarayana
Sep 14, 2016·Drug Development and Industrial Pharmacy·F H Xavier-JuniorE S T Egito
Dec 23, 2016·The Journal of Physical Chemistry. B·Muhammad Faizan NazarMuhammad Zubair
Sep 28, 2017·Human Vaccines & Immunotherapeutics·Chao LiuGang Liu
Feb 26, 2020·Pharmaceutics·Seol Hwa SeoKang-Yell Choi

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