Microemulsion Using Polyoxyethylene Sorbitan Trioleate and its Usage for Skin Delivery of Resveratrol to Protect Skin against UV-Induced Damage

Chemical & Pharmaceutical Bulletin
Reiko YutaniShuji Kitagawa

Abstract

We examined the phase behavior of various polyoxyethylene sorbitan fatty acid ester (polysorbates)/ethanol/isopropyl myristate (IPM)/150 mM NaCl solution (NaClaq) systems in order to prepare a microemulsion containing a low ratio of ethanol, which is more suitable for in vivo application. Using polyoxyethylene sorbitan trioleate (Tween 85), which has a large lipophilic moiety, as a surfactant component, single-phase domain of the phase diagram was the largest of all the polysorbates examined, and in particular a large oil-rich single-phase domain was obtained. When the ratio of Tween 85 to ethanol was changed from 1 : 1 to 3 : 1, the oil-rich single-phase domain further expanded, which led to a reduced ethanol concentration in the preparation. Thus, we determined the composition of the microemulsion to be Tween 85 : ethanol : IPM : NaClaq=30 : 10 : 53 : 7, and used it for skin delivery of resveratrol. Microemulsion gel was also prepared by adding 6.5% Aerosil) 200 into the microemulsion for ease of topical application. When applied with each vehicle, delivery of resveratrol into guinea pig skin in vitro was significantly enhanced compared with that by IPM, and resveratrol incorporated into the skin by microemulsion gel decrease...Continue Reading

References

Dec 4, 2002·Advanced Drug Delivery Reviews·Mads Kreilgaard
Aug 3, 2006·Experimental Dermatology·Farrukh Afaq, Hasan Mukhtar
Aug 1, 2008·Nutrition Reviews·Chibuike C UdenigwePeter J H Jones
Aug 23, 2008·International Journal of Pharmaceutics·C CaddeoJ Kristl
Jul 11, 2009·The Journal of Pharmacy and Pharmacology·Shuji KitagawaAkiko Yoshii
Nov 10, 2009·Archives of Dermatological Research·Joi A Nichols, Santosh K Katiyar

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Citations

May 19, 2016·Journal of Natural Products·Andressa T FujimuraRubia Casagrande
Jan 28, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Poonam NegiO P Katare
Jan 8, 2017·Photochemistry and Photobiology·Mary K Montes de OcaFarrukh Afaq
Oct 5, 2019·Current Pharmaceutical Design·Carmelo Puglia, Debora Santonocito
Jun 5, 2021·Royal Society Open Science·Sunnam KimSeiji Kurihara
Nov 10, 2021·Pharmaceutical Development and Technology·Ghada M El-Zaafarany, Maha Nasr

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