PMID: 11604263Oct 18, 2001Paper

Microencapsulation of dissociable human growth hormone aggregates within poly(D,L-lactic-co-glycolic acid) microparticles for sustained release

International Journal of Pharmaceutics
H K Kim, Tae Gwan Park

Abstract

For the sustained release formulation of recombinant human growth hormone (rhGH), dissociable rhGH aggregates were microencapsulated within poly(D,L-lactic-co-glycolic acid) (PLGA) microparticles. rhGH aggregates were first produced by adding a small volume of aqueous rhGH solution into a partially water miscible organic solvent phase (ethyl acetate, EtAc) containing PLGA. These rhGH aggregates were then microencapsulated within PLGA polymer phase by extracting EtAc into an aqueous phase pre-saturated with EtAc. Release profiles of rhGH from these microparticles were greatly affected by changing the volume of incubation medium. The released rhGH species consisted of mostly monomeric form having a correct conformation. This study reveals that sustained rhGH release could be achieved by microencapsulating reversibly dissociable protein aggregates within biodegradable polymers.

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Citations

Mar 20, 2010·Pharmaceutical Research·Keizo FukushimaKanji Takada
Aug 23, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fan Tao MengZhi Guo Su
Nov 7, 2008·Journal of Biomaterials Applications·Anthony V CaparsoJoseph M Mansour
Aug 2, 2008·Biological & Pharmaceutical Bulletin·Yukako ItoKanji Takada
Aug 30, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Martin Körber, Roland Bodmeier
Dec 29, 2007·International Journal of Pharmaceutics·A GiteauJ P Benoit
Mar 12, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Frederic LagarceJean-Pierre Benoit
Feb 4, 2014·Pharmaceutical Development and Technology·Soliman Mohammadi-Samani, Behzad Taghipour
Nov 2, 2013·Journal of Microencapsulation·Jukyung KangHongkee Sah
Sep 13, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·M R MorenoR Agrawal
Apr 28, 2009·Journal of Colloid and Interface Science·Li LiuLiang-Yin Chu
Feb 9, 2005·Journal of Biomaterials Science. Polymer Edition·Jun Bae LeeTae Gwan Park
Mar 12, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ugo BilatiEric Doelker
May 9, 2006·Treatments in Endocrinology·Andreas Jostel, Stephen M Shalet
Nov 27, 2007·Journal of Tissue Engineering and Regenerative Medicine·G A SilvaR L Reis
Jun 9, 2005·Journal of Peptide Science : an Official Publication of the European Peptide Society·V SaroglouC Demetzos
Apr 4, 2015·Annals of Biomedical Engineering·Christian R Osswald, Jennifer J Kang-Mieler

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