PMID: 9423844Jan 10, 1998Paper

Microevolution of a standard strain of Cryptococcus neoformans resulting in differences in virulence and other phenotypes

Infection and Immunity
S P FranzotA Casadevall

Abstract

Cryptococcus neoformans is a major fungal pathogen for patients with debilitated immune systems. However, no information is available on the stability of virulence or of phenotypes associated with virulence for C. neoformans laboratory strains. A serendipitous observation in our laboratory that one isolate of C. neoformans ATCC 24067 (strain 52D) became attenuated after continuous in vitro culture prompted us to perform a comparative study of nine strain 24067 isolates obtained from six different research laboratories. Each isolate was characterized by DNA typing, virulence for mice, proteinase production, extracellular protein synthesis, melanin synthesis, carbon assimilation pattern, antifungal drug susceptibility, colony morphology, growth rate, agglutination titers, phagocytosis by murine macrophages, capsule size, and capsular polysaccharide structure. All isolates had similar DNA typing patterns consistent with their assignment to the same strain, although minor chromosome size polymorphisms were observed in the electrophoretic karyotypes of two isolates. Several isolates had major differences in phenotypes that may be associated with virulence, including growth rate, capsule size, proteinase production, and melanization....Continue Reading

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Citations

Apr 3, 2001·Microbiology·T BoekhoutW Meyer
Mar 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carlos P TabordaArturo Casadevall
Aug 13, 2003·Eukaryotic Cell·Indrani BoseTamara L Doering
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Johanna Rivera, Arturo Casadevall
Jan 31, 2007·Applied and Environmental Microbiology·N JainB C Fries
Feb 22, 2007·FEMS Yeast Research·Ana Marisa Fusco AlmeidaUNKNOWN Laboratory Group on Cryptococcosis
Sep 4, 2015·G3 : Genes - Genomes - Genetics·Jeanine M RefsniderErica Bree Rosenblum
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·D L GoldmanA Casadevall
Feb 11, 2005·Eukaryotic Cell·James A FraserJoseph Heitman
Apr 5, 2003·Cellular Microbiology·Joshua D Nosanchuk, Arturo Casadevall
Mar 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Johanna RiveraArturo Casadevall
May 25, 2004·Infection and Immunity·Dea Garcia-HermosoGuilhem Janbon
Jun 24, 2008·Mycopathologia·Neena Jain, Bettina C Fries
May 18, 2006·Annual Review of Microbiology·Xiaorong Lin, Joseph Heitman
Aug 21, 2010·Future Microbiology·Michal A OlszewskiGary B Huffnagle
Jan 27, 2000·Medical Mycology·A J Hamilton, M D Holdom
Nov 23, 2005·Revista Do Instituto De Medicina Tropical De São Paulo·Cilmery S KurokawaMaria T S Peraçoli
Feb 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·N LendvaiA Casadevall
Dec 6, 2001·The Journal of Clinical Investigation·B C FriesA Casadevall
Dec 21, 2007·Memórias do Instituto Oswaldo Cruz·Marilena A MartinsVera L Pereira-Chioccola

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