Apr 12, 2016

Microevolution of Bank Voles (Myodes glareolus) at Neutral and Immune Related Genes During Multiannual Dynamic Cycles: Consequences for Puumala hantavirus Epidemiology

BioRxiv : the Preprint Server for Biology
Adelaide DuboisNathalie Charbonnel


Understanding how host dynamics, including spatiotemporal variations of population size and dispersal, may affect the epidemiology of infectious diseases is an active research area. Population dynamics drive neutral and adaptive micro-evolutionary processes that in turn, influence pathogens persistence, their distribution and evolution. This study focuses on a bank vole (Myodes glareolus) metapopulation surveyed in Finland between 2005 and 2009. Bank vole is the reservoir of Puumala hantavirus (PUUV), the agent of nephropathia epidemica (NE, a mild form of hemorrhagic fever with renal symptom) in humans. M glareolus populations experience multiannual density fluctuations that influence the level of genetic diversity maintained in bank voles, variations in PUUV prevalence and NE occurrence in humans. Here, we examine bank vole metapopulation genetics at presumably neutral markers and immune-related genes (Tnf-promoter, Mhc-Drb, Tlr4, Tlr7 and Mx2 gene). We discuss its potential consequences on PUUV epidemiology. Using microsatellites, we show that genetic drift slightly and transiently affects neutral and adaptive genetic variability within the metapopulation. Gene flow seems to counterbalance its effects during the multiannual ...Continue Reading

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Mentioned in this Paper

Genetic Drift
Biological Markers
Immune Response
TLR7 protein, human
TLR4 gene
Nephropathia Epidemica

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