Microfabricaton of microfluidic check valves using comb-shaped moving plug for suppression of backflow in microchannel

Biomedical Microdevices
Jini Hyeon, Hongyun So

Abstract

This study reports on an efficient microscale one-way valve system that combines the physical properties of photopolymerized microstructures and viscoelastic microchannels to rectify flows with low Reynolds numbers. The comb-shaped moving plug in the microchannel prevented backflow in the closed state to ensure that the microchannel remained completely blocked in the closed state, but allowed forward flow in the open state. This microfluidic check valve was microfabricated using the combination of the soft lithography and the releasing methods with the use of a double photoresist layer to create microchannels and free-moving comb-shaped microstructures, respectively. As a result, the microfluidic check valves elicited average high-pressure differences as much as 10.75 kPa between the backward and forward flows at low Reynolds numbers of the order of 0.253, thus demonstrating efficient rectification of microfluids. This study supports the use of rectification systems for the development of biomedical devices, such as drug delivery, micropumps, and lab-on-a-chip, by allowing unidirectional flow.

References

Feb 24, 2001·Analytical Chemistry·E T LagallyR A Mathies
Sep 28, 2002·Science·Todd ThorsenStephen R Quake
Oct 17, 2002·Analytical Chemistry·Ernest F HasselbrinkJason E Rehm
Dec 25, 2002·Journal of Chromatography. a·Brian J KirbyErnest F Hasselbrink
Mar 17, 2004·Nature Biotechnology·Jong Wook HongStephen R Quake
Apr 20, 2004·Physical Review Letters·Alex Groisman, Stephen R Quake
Sep 18, 2004·Analytical Chemistry·David S ReichmuthBrian J Kirby
Feb 7, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Hans M WyssDavid A Weitz
Feb 4, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Arkadij M ElizarovJames R Heath
Nov 13, 2012·Advances in Colloid and Interface Science·Christophe HenryGrégory Lefèvre

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Citations

Oct 28, 2019·Sensors·Sean C MorganVincent J Sieben
May 15, 2021·Scientific Reports·Aryan Mehboudi, Junghoon Yeom

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