PMID: 4035940Jul 1, 1985Paper

Microfilarial granulomas in the spleens of wild-caught cynomolgus monkeys (Macaca fascicularis)

Veterinary Pathology
I NaramaM Tsuchitani


Splenic nodules from 38 cynomolgus monkeys (Macaca fascicularis) which were captured in Malaysia and Indonesia were studied histologically. The lesions were characterized by well-circumscribed focal fibrosis, accumulation of eosinophils and histiocytes, hemorrhage or hemosiderosis, and loss of normal splenic architecture. Small arteries in the lesion frequently had intimal thickening and narrowing of the lumen in addition to the presence of microfilariae. Microfilariae were also seen in the extravascular area of the lesion, and were occasionally engulfed by multinucleated giant cells. The splenic lesion was thought to have been initiated by incomplete infarction caused by intimal thickening and microfilarial occupation of the small arteries.


May 1, 1982·The American Journal of Tropical Medicine and Hygiene·S SucharitW Choochote
Jun 1, 1955·Annals of Tropical Medicine and Parasitology·W A WEBBER
Jan 1, 1965·Transactions of the Royal Society of Tropical Medicine and Hygiene·F HAWKINGP J WALKER

Related Concepts

Macaca fascicularis
Monkey Diseases
Nematode Infections
Splenic Diseases

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