PMID: 15220668Jun 29, 2004Paper

Microflora in inflammatory bowel diseases: a pediatric perspective

Journal of Clinical Gastroenterology
Eugenia BruzzeseA Guarino

Abstract

Several lines of evidence link inflammatory bowel diseases to modifications of intestinal microflora. Epidemiologic and clinical data suggest a triggering role for select agents in ulcerative colitis and in Crohn disease. Experimental evidence indicates that intestinal microorganisms are needed for developing intestinal inflammation in IL-10 knockout mice, and this is associated with an increased number of adherent clostridia and a decrease of lactobacilli and bifidobacteria. It may be hypothesized that a host-agent-specific relationship leads to an abnormal immune response, which may be genetically driven in select inflammatory bowel diseases. However, different from adults, the pattern of intestinal microflora undergoes profound changes during the early stage of life, contributing to the development of the immune system. A close relationship exists between microbiologic and immunologic imprinting. The microbiologic imprinting in neonates may be modified using bacterial probiotics that colonize the intestine, modify the immune response, and decrease the risk for atopy. Probiotics may decrease the recurrences of inflammatory bowel diseases. Preliminary evidence of intestinal antiinflammatory effects has been detected in childre...Continue Reading

References

Jun 2, 2000·Gastroenterology·K L MadsenR N Fedorak
Oct 25, 2000·Journal of Pediatric Gastroenterology and Nutrition·P GuptaS Guandalini
Jan 10, 2001·The Journal of Allergy and Clinical Immunology·M KalliomäkiE Isolauri
Jan 10, 2002·Gastroenterology·Alexander SwidsinskiHerbert Lochs
May 11, 2002·The American Journal of Gastroenterology·Christel NeutJean-Fredéric Colombel
Jul 4, 2002·The American Journal of Gastroenterology·Roberto Berni CananiAlfredo Guarino
Oct 11, 2002·Scandinavian Journal of Gastroenterology·B KleessenM Blaut
Nov 7, 2002·European Journal of Nutrition·Arthur OuwehandSeppo Salminen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

Current Opinion in Gastroenterology
Karen L Krok, Gary R Lichtenstein
Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie
Alexandra FrolkisAlberta IBD Consortium
Nihon rinsho. Japanese journal of clinical medicine
Kiichiro Tsuchiya, Mamoru Watanabe
© 2022 Meta ULC. All rights reserved