Microfluidic and Paper-Based Devices for Disease Detection and Diagnostic Research

International Journal of Molecular Sciences
Joshua M CampbellAdam T Melvin

Abstract

Recent developments in microfluidic devices, nanoparticle chemistry, fluorescent microscopy, and biochemical techniques such as genetic identification and antibody capture have provided easier and more sensitive platforms for detecting and diagnosing diseases as well as providing new fundamental insight into disease progression. These advancements have led to the development of new technology and assays capable of easy and early detection of pathogenicity as well as the enhancement of the drug discovery and development pipeline. While some studies have focused on treatment, many of these technologies have found initial success in laboratories as a precursor for clinical applications. This review highlights the current and future progress of microfluidic techniques geared toward the timely and inexpensive diagnosis of disease including technologies aimed at high-throughput single cell analysis for drug development. It also summarizes novel microfluidic approaches to characterize fundamental cellular behavior and heterogeneity.

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Citations

Aug 28, 2020·Reviews in Medical Virology·Arefeh BasiriNima Rezaei
Aug 7, 2019·Micromachines·Veasna SoumKwanwoo Shin
Dec 29, 2019·Scientific Reports·Krystian L WlodarczykM Mercedes Maroto-Valer
Apr 1, 2021·Emergent Materials·E Alperay TarimH Cumhur Tekin
Dec 11, 2019·Talanta·Ruchita ShandilyaPradyumna Kumar Mishra
Nov 10, 2020·Chemical Engineering Journal·Shikandar D BukkitgarTejraj M Aminabhavi
Jun 24, 2021·Analytical Chemistry·Lei WangJianhan Lin
Jul 3, 2021·Infectious Disease Reports·Peuli NathAniruddha Ray

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Methods Mentioned

BETA
ELISA
chip
chips
flow
flow cytometry
nucleic acid amplification
surface-enhanced Raman scattering
sandwich immunoassay
PCA
motility studies

Software Mentioned

Fluidigm
demuxlet
SISSOR
seq2
Drop
Smart

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