Microfluidic approach for rapid multicomponent interfacial tensiometry

Lab on a Chip
João T Cabral, Steven D Hudson

Abstract

We report a microfluidic instrument to rapidly measure the interfacial tension of multi-component immiscible liquids. The measurement principle rests upon the deformation and retraction dynamics of drops under extensional flow and was implemented for the first time in microfluidics (S. D. Hudson et al., Appl. Phys. Lett., 2005, 87, 081905 (ref. )). Here we describe in detail the instrument design and physics and extend this principle to investigate multicomponent mixtures, specifically two-component drops of adjustable composition. This approach provides fast real-time sigma measurements (on the order of 1 s), the possibility of rapidly adjusting drop composition and utilizes small sample volumes (approximately 10 microL). The tensiometer operation is illustrated with water drops and binary drops (water/ethylene glycol mixtures) in silicone oils. The technique should be particularly valuable for high-throughput characterization of complex fluids.

References

May 1, 2001·Physical Review Letters·T ThorsenS R Quake
Aug 2, 2001·Nature Biotechnology·P Mitchell
Jan 25, 2002·Analytical Chemistry·Timothy J JohnsonLaurie E Locascio
Jan 26, 2002·Science·Abraham D StroockGeorge M Whitesides
Feb 22, 2003·Angewandte Chemie·Helen SongRustem F Ismagilov
May 3, 2003·Journal of Colloid and Interface Science·T F SvitovaC J Radke
Sep 23, 2003·Angewandte Chemie·Rustem F Ismagilov
Oct 2, 2003·Nature Biotechnology·Jong Wook Hong, Stephen R Quake
Mar 6, 2004·Physical Review Letters·D R LinkH A Stone
Nov 3, 2004·Langmuir : the ACS Journal of Surfaces and Colloids·João T CabralJack F Douglas
May 21, 2005·Physical Review Letters·Piotr GarsteckiGeorge M Whitesides
Dec 1, 1998·Analytical Chemistry·D C DuffyG M Whitesides

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Citations

Mar 28, 2012·Analytical and Bioanalytical Chemistry·Zhi ZhuChaoyong James Yang
May 27, 2011·Journal of Biological Engineering·Mandy Ly SinPak Kin Wong
Apr 4, 2014·Soft Matter·Quentin BrosseauJean-Christophe Baret
Jun 17, 2014·Soft Matter·Ayako YamadaCharles N Baroud
Jan 31, 2008·Lab on a Chip·Shia-Yen TehAbraham P Lee
Mar 29, 2012·Lab on a Chip·Linas Mazutis, Andrew D Griffiths
Jun 1, 2012·Lab on a Chip·Riëlle de RuiterFrieder Mugele
Dec 30, 2015·Environmental Science & Technology·Andrew Richard MetcalfCari S Dutcher
Apr 24, 2012·Journal of Colloid and Interface Science·Kendra A ErkSteven D Hudson
Nov 26, 2008·Journal of Colloid and Interface Science·Shaowei LiGuangsheng Luo
Aug 12, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Leonard M C Sagis
Nov 7, 2006·Angewandte Chemie·Helen SongRustem F Ismagilov
Mar 16, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Kai WangGuangsheng Luo
Aug 28, 2010·Advanced Materials·Jeffrey D MartinSteven D Hudson
Jun 2, 2009·Advances in Colloid and Interface Science·Philipp ErniPeter Fischer
Jul 3, 2010·Advances in Colloid and Interface Science·Stefano Guido, Valentina Preziosi
Jul 21, 2015·The Journal of Physical Chemistry. B·Carolina Bermúdez-Salguero, Jesús Gracia-Fadrique
Feb 24, 2015·Soft Matter·Ingmar PolenzJean-Christophe Baret
Nov 17, 2012·Lab on a Chip·Scott S H TsaiHoward A Stone
Oct 21, 2011·Lab on a Chip·Jean-Christophe Baret
Apr 6, 2017·Lab on a Chip·Marco AdamoJoão T Cabral
May 13, 2017·The Journal of Physical Chemistry. a·Hallie C Boyer, Cari S Dutcher
Jul 14, 2017·Analytical Chemistry·Myungwha ChungAkihide Hibara
Jul 11, 2014·Nature Communications·Su Ji ParkJung Ho Je
Jan 3, 2019·Soft Matter·Massimiliano M VillonePier Luca Maffettone
Nov 22, 2007·Lab on a Chip·Natasha PatritoPeter R Norton
Oct 3, 2018·Biomicrofluidics·Francisco PimentaManuel A Alves
Dec 1, 2019·Scientific Reports·Michael F ThorneAnna G Slater
Jan 13, 2016·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Akihide HibaraMikhail A Proskurnin
Mar 20, 2019·Soft Matter·Corentin TrégouëtMathilde Reyssat
Feb 6, 2017·Lab on a Chip·Doojin LeeAmy Q Shen
Nov 13, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Jing LiuNam-Trung Nguyen
Dec 18, 2013·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Martin Sauzade, Thomas Cubaud
Mar 20, 2021·Advances in Colloid and Interface Science·Antonio PerazzoSergio Caserta
Sep 13, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·J H XuG S Luo
Feb 21, 2021·Annual Review of Physical Chemistry·Priyatanu RoyCari S Dutcher
May 6, 2021·Lab on a Chip·Davood KhoeiniAdrian Neild
Oct 30, 2019·Biomacromolecules·Jie SongPatrick T Spicer
Jun 28, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Kaiqiang ZhangLirong Liu
Apr 13, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Rosa D'ApolitoStefano Guido
Feb 15, 2018·The Journal of Physical Chemistry. B·Nadia Shardt, Janet A W Elliott
Nov 6, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Yongjin CuiGuangsheng Luo
Jan 25, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Lawrence W HonakerV S R Jampani
Dec 4, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Yun ChenCari S Dutcher

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