Microfluidic-Based Approaches in Targeted Cell/Particle Separation Based on Physical Properties: Fundamentals and Applications.

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Rohollah NasiriAli Khademhosseini

Abstract

Cell separation is a key step in many biomedical research areas including biotechnology, cancer research, regenerative medicine, and drug discovery. While conventional cell sorting approaches have led to high-efficiency sorting by exploiting the cell's specific properties, microfluidics has shown great promise in cell separation by exploiting different physical principles and using different properties of the cells. In particular, label-free cell separation techniques are highly recommended to minimize cell damage and avoid costly and labor-intensive steps of labeling molecular signatures of cells. In general, microfluidic-based cell sorting approaches can separate cells using "intrinsic" (e.g., fluid dynamic forces) versus "extrinsic" external forces (e.g., magnetic, electric field, etc.) and by using different properties of cells including size, density, deformability, shape, as well as electrical, magnetic, and compressibility/acoustic properties to select target cells from a heterogeneous cell population. In this work, principles and applications of the most commonly used label-free microfluidic-based cell separation methods are described. In particular, applications of microfluidic methods for the separation of circulating...Continue Reading

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Citations

Sep 11, 2020·Lab on a Chip·Wenlai TangNan Xiang
Apr 20, 2021·Analytica Chimica Acta·Navya RastogiProsenjit Sen
Jun 3, 2021·Gels·Bibi Noorheen Haleema Mooneerah NeerooaSin-Yeang Teow
Jul 3, 2021·Journal of Colloid and Interface Science·Razie Khalesi MoghaddamGiovanniantonio Natale
Jul 6, 2021·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Seyed Ali Tabatabaei, Mohammad Zabetian Targhi
Jul 23, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Bozhen ZhangXimin He
Aug 4, 2021·The Journal of the Acoustical Society of America·Mehrshad Rezadoost DezfuliMajid Ghassemi
Aug 7, 2021·Micromachines·Peter E BeshayYasser H Anis
Nov 16, 2021·Biofabrication·Leyla AmirifarAli Khademhosseini

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