Microfluidic-based sperm sorting & analysis for treatment of male infertility

Translational Andrology and Urology
Raheel SamuelBruce K Gale

Abstract

Microfluidics technology has emerged as an enabling technology for different fields of medicine and life sciences. One such field is male infertility where microfluidic technologies are enabling optimization of sperm sample preparation and analysis. In this chapter we review how microfluidic technology has been used for sperm quantification, sperm quality analysis, and sperm manipulation and isolation with subsequent use of the purified sperm population for treatment of male infertility. As we discuss demonstrations of microfluidic sperm sorting/manipulation/analysis, we highlight systems that have demonstrated feasibility towards clinical adoption or have reached commercialization in the male infertility market. We then review microfluidic-based systems that facilitate non-invasive identification and sorting of viable sperm for in vitro fertilization. Finally, we explore commercialization challenges associated with microfluidic sperm sorting systems and provide suggestions and future directions to best overcome them.

Citations

Aug 17, 2019·Journal of Assisted Reproduction and Genetics·Alessandra ParrellaGianpiero D Palermo
Dec 9, 2020·Scientific Reports·Alex JafekRaheel Samuel
Jan 17, 2021·Systems Biology in Reproductive Medicine·Fatemeh AnbariMojdeh Sabour
Mar 5, 2021·Journal of Assisted Reproduction and Genetics·Sandra Lara-CerrilloAgustín García-Peiró
Mar 14, 2021·Fertility and Sterility·Amber M KlimczakRichard T Scott
Apr 4, 2021·Journal of Clinical Medicine·Caroline KangPeter N Schlegel
May 1, 2021·Animals : an Open Access Journal From MDPI·Andra-Sabina Neculai-Valeanu, Adina Mirela Ariton
Jul 28, 2021·Zygote : the Biology of Gametes and Early Embryos·A PujolR Vassena
Aug 21, 2021·Physical Review. E·Simone Coppola, Vasily Kantsler
Apr 15, 2021·Endocrinology·Vedant V Bodke, Joanna E Burdette
Jan 27, 2022·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ali LesaniMahdi Moghimi Zand
Dec 31, 2021·Endocrine Reviews·Eisa Tahmasbpour MarzouniElena Jane Tucker

❮ Previous
Next ❯

Methods Mentioned

BETA
optical tweezers
chip
biopsy
electrophoresis
Raman
chips

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved