Microfluidic-controlled manufacture of liposomes for the solubilisation of a poorly water soluble drug

International Journal of Pharmaceutics
Elisabeth KastnerYvonne Perrie

Abstract

Besides their well-described use as delivery systems for water-soluble drugs, liposomes have the ability to act as a solubilizing agent for drugs with low aqueous solubility. However, a key limitation in exploiting liposome technology is the availability of scalable, low-cost production methods for the preparation of liposomes. Here we describe a new method, using microfluidics, to prepare liposomal solubilising systems which can incorporate low solubility drugs (in this case propofol). The setup, based on a chaotic advection micromixer, showed high drug loading (41 mol%) of propofol as well as the ability to manufacture vesicles with at prescribed sizes (between 50 and 450 nm) in a high-throughput setting. Our results demonstrate the ability of merging liposome manufacturing and drug encapsulation in a single process step, leading to an overall reduced process time. These studies emphasise the flexibility and ease of applying lab-on-a-chip microfluidics for the solubilisation of poorly water-soluble drugs.

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Citations

Jan 5, 2016·Trends in Biotechnology·Andrew B HillCharles H Jones
Nov 19, 2015·Advanced Drug Delivery Reviews·Yvonne PerrieVinod Nadella
Aug 6, 2016·Journal of Drug Targeting·Shyam GargEuan Ramsay
Aug 4, 2016·ACS Applied Materials & Interfaces·Isabel Ortiz de SolorzanoManuel Arruebo
Sep 21, 2016·Pharmaceutics·Carla B RocesYvonne Perrie
May 20, 2016·Scientific Reports·Dario CarugoClaudio Nastruzzi
Mar 8, 2018·Advanced Materials·Roberto MolinaroEnnio Tasciotti
Jun 29, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·M Marín-GarcíaR Barnadas-Rodríguez
Oct 21, 2019·Pharmaceutical Nanotechnology·Sarah StreckArlene McDowell
Feb 19, 2020·Journal of Liposome Research·Chandra Has, Sharadwata Pan
Jun 26, 2020·Food & Function·Shan HeColin L Raston
Oct 12, 2018·Drug Delivery and Translational Research·Mahsa SedighiDominik Witzigmann
Oct 5, 2019·Pharmaceutical Nanotechnology·Linda HongBen J Boyd
Sep 29, 2019·Journal of Liposome Research·C Has, P Sunthar
Jan 10, 2021·Colloids and Surfaces. B, Biointerfaces·Clarinda CostaM Luísa Corvo
Oct 21, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Eri SasakiYoichi Negishi
Mar 27, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alejandro ForiguaKatherine S Elvira
Nov 20, 2016·International Journal of Pharmaceutics·Sameer JoshiYvonne Perrie
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May 21, 2021·International Journal of Pharmaceutics·Leonidas GkionisAnnalisa Tirella
May 30, 2021·Colloids and Surfaces. B, Biointerfaces·Paulina Skupin-MrugalskaHanna Piotrowska-Kempisty
Jul 17, 2021·Global Challenges·Pantelitsa DimitriouDavid Barrow
Jan 14, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Takeshi TeradaPieter R Cullis

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