Microfluidic Diatomite Analytical Devices for Illicit Drug Sensing with ppb-Level Sensitivity

Sensors and Actuators. B, Chemical
Xianming KongAlan X Wang

Abstract

The escalating research interests in porous media microfluidics, such as microfluidic paper-based analytical devices, have fostered a new spectrum of biomedical devices for point-of-care (POC) diagnosis and biosensing. In this paper, we report microfluidic diatomite analytical devices (μDADs), which consist of highly porous photonic crystal biosilica channels, as an innovative lab-on-a-chip platform to detect illicit drugs. The μDADs in this work are fabricated by spin-coating and tape-stripping diatomaceous earth on regular glass slides with cross section of 400×30µm2. As the most unique feature, our μDADs can simultaneously perform on-chip chromatography to separate small molecules from complex biofluidic samples and acquire the surface-enhanced Raman scattering spectra of the target chemicals with high specificity. Owing to the ultra-small dimension of the diatomite microfluidic channels and the photonic crystal effect from the fossilized diatom frustules, we demonstrate unprecedented sensitivity down to part-per-billion (ppb) level when detecting pyrene (1ppb) from mixed sample with Raman dye and cocaine (10 ppb) from human plasma. This pioneering work proves the exclusive advantage of μDADs as emerging microfluidic devices...Continue Reading

References

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Citations

Sep 18, 2020·Bulletin of Environmental Contamination and Toxicology·Mingtao Li, Xiang Zhang
Dec 5, 2019·Sensors·Ilaria Rea, Luca De Stefano
Jan 2, 2021·Forensic Science International : Synergy·Nicole S Jones, Jeffrey H Comparin
Jan 26, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Siqingaowa HanWuliji Hasi
Feb 12, 2020·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Sijia LiuAlan X Wang
Feb 26, 2021·Journal of Separation Science·Ling Xia, Gongke Li
Apr 20, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Xiaoran TianXianming Kong
Jul 21, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Xiaoran TianXianming Kong

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