Microfluidic fabrication of microparticles for biomedical applications

Chemical Society Reviews
Wen LiDavid A Weitz

Abstract

Droplet microfluidics offers exquisite control over the flows of multiple fluids in microscale, enabling fabrication of advanced microparticles with precisely tunable structures and compositions in a high throughput manner. The combination of these remarkable features with proper materials and fabrication methods has enabled high efficiency, direct encapsulation of actives in microparticles whose features and functionalities can be well controlled. These microparticles have great potential in a wide range of bio-related applications including drug delivery, cell-laden matrices, biosensors and even as artificial cells. In this review, we briefly summarize the materials, fabrication methods, and microparticle structures produced with droplet microfluidics. We also provide a comprehensive overview of their recent uses in biomedical applications. Finally, we discuss the existing challenges and perspectives to promote the future development of these engineered microparticles.

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Citations

Sep 20, 2019·Small·Jing LuoShutao Wang
Sep 14, 2019·Small·Irvine Lian Hao Ong, Esther Amstad
Oct 2, 2019·Small·Lifei ZhuXuechang Zhou
Nov 22, 2019·Chemical Society Reviews·Youchuang Chao, Ho Cheung Shum
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Jul 10, 2019·Advanced Materials·Haitao LiuJianhua Qin
Oct 20, 2020·Advanced Healthcare Materials·Sungjin JungYongTae Kim
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Nov 17, 2020·Biomicrofluidics·Mao-Jie ZhangLiang-Yin Chu
Nov 18, 2020·Advanced Drug Delivery Reviews·Christian Isalomboto NkangaFarshad Ramazani
Apr 2, 2021·Journal of Experimental Orthopaedics·Nicholas N DePhillipoPhilippe Beaufils
Mar 30, 2021·Advanced Drug Delivery Reviews·Matthew A BorrelliSteven R Little

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Methods Mentioned

BETA
flow lithography
biosensors
chips
chip
fluorescence-activated cell sorting
single cell sequencing
inDrop
biosensor
biosensing
microsensors

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