Microfluidic immunomagnetic multi-target sorting--a model for controlling deflection of paramagnetic beads

Lab on a Chip
Scott S H TsaiHoward A Stone

Abstract

We describe a microfluidic system that uses a magnetic field to sort paramagnetic beads by deflecting them in the direction normal to the flow. In the experiments we systematically study the dependence of the beads' deflection on bead size and susceptibility, magnet strength, fluid speed and viscosity, and device geometry. We also develop a design parameter that can aid in the design of microfluidic devices for immunomagnetic multi-target sorting.

References

Jan 1, 1990·Cytometry·S MiltenyiA Radbruch
Jan 25, 2003·Molecular & Cellular Proteomics : MCP·Alexander S Brodsky, Pamela A Silver
Oct 20, 2005·Lab on a Chip·Christian Mikkelsen, Henrik Bruus
Jul 29, 2006·Lab on a Chip·Nicole Pamme, Claire Wilhelm
Sep 27, 2007·Lab on a Chip·Sergey S ShevkoplyasGeorge M Whitesides
Nov 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jonathan D AdamsH Tom Soh
Apr 17, 2009·Lab on a Chip·Chong Wing YungDonald E Ingber
Feb 18, 2010·Journal of Magnetism and Magnetic Materials·Chris CarrJohn Martin

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Citations

Dec 20, 2013·Analytical Chemistry·Tao SunJoel Voldman
Sep 27, 2014·Lab on a Chip·Nicolas C PégardJason W Fleischer
Feb 9, 2016·Soft Matter·Steven G JonesScott S H Tsai
Dec 12, 2013·Advanced Materials·Navid HakimiDae Kun Hwang
Nov 17, 2012·Lab on a Chip·Scott S H TsaiHoward A Stone

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