Microfluidic light scattering as a tool to study the structure of aqueous polymer solutions

Journal of Colloid and Interface Science
Alexander I NormanEric J Amis

Abstract

A small-angle light scattering (SALS) apparatus, coupled with a specially designed microfluidic device is shown to monitor the formation and subsequent size distribution of giant multilamellar vesicles of a diblock copolymer in aqueous solution. The closed-face design, fabricated between glass slides using a UV-curable optical adhesive, incorporates multiple inlets, a mixing system, and a viewing window to perform on-line SALS. The mixing of each component is tested using polystyrene latex microspheres. Vesicles of the block copolymer, EO6BO11 in aqueous solution are formed on the SALS chip and the pair distance distribution function determined using an inverse Fourier transformation of the scattered intensity to quantify the population and distribution for a range of vesicle sizes. These experiments provide demonstrations of how SALS on a microfluidic device can be used as a rapid screening tool to optimize processing conditions for a range of polymer solutions.

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Citations

Aug 4, 2007·The Review of Scientific Instruments·Thomas Q ChastekEric J Amis
Dec 25, 2008·Lab on a Chip·Kazunori IidaMichael J Fasolka
Jun 14, 2018·Journal of Applied Crystallography·Carlos G LopezJoão T Cabral
Jul 3, 2021·Chemical Reviews·Farhad SoheilmoghaddamJustin Cooper-White

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