Microfluidic methods for production of liposomes.

Methods in Enzymology
Bo YuL James Lee

Abstract

Liposomes are composed of lipid bilayer membranes that encapsulate an aqueous volume. A major challenge in the development of liposomes for drug delivery is the control of size and size distribution. In conventional methods, lipids are spontaneously assembled into heterogeneous bilayers in a bulk phase. Additional processing by extrusion or sonication is required to obtain liposomes with small size and a narrow size distribution. Microfluidics is an emerging technology for liposome synthesis, because it enables precise control of the lipid hydration process. Here, we describe a number of microfluidic methods that have been reported to produce micro/nanosized liposomes with narrower size distribution in a reproducible manner, focusing on the use of continuous-flow microfluidics. The advantages of liposome formation using the microfluidic approach over traditional bulk-mixing approaches are discussed.

Citations

Nov 17, 2015·Molecular Pharmaceutics·Anthony D DuongKristy M Ainslie
May 14, 2016·Journal of Liposome Research·Kalpa NagarsekarAlfred Fahr
Aug 6, 2016·Journal of Drug Targeting·Shyam GargEuan Ramsay
Oct 11, 2016·Chemical Society Reviews·N GrimaldiN Ventosa
Mar 31, 2015·Life·David M Miller, Jacqueline M Gulbis
Mar 31, 2018·Nature Protocols·Siddharth Deshpande, Cees Dekker
Sep 5, 2018·Chemical Society Reviews·Emeline RideauKatharina Landfester
Aug 9, 2016·Interface Focus·Chiara Martino, Andrew J deMello
Mar 1, 2020·International Journal of Molecular Sciences·M D Al-AminPaolo Caliceti
Mar 2, 2018·Biological & Pharmaceutical Bulletin·Takahiro Muraoka
Dec 1, 2018·Nano Convergence·You Jung KangHansang Cho
Jul 28, 2019·Pharmaceutics·Anna Angela BarbaGaetano Lamberti
May 22, 2019·Current Pharmaceutical Design·Anilkumar T SJyh-Ping Chen
Apr 19, 2020·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Ruba BnyanTouraj Ehtezazi
May 15, 2020·Pharmaceutics·Sabrina BochicchioAnna Angela Barba
Jan 9, 2021·Expert Opinion on Drug Delivery·José Javier López-CanoIrene Teresa Molina-Martínez
Dec 3, 2020·Micromachines·Andres ArangurenJuan C Cruz
Nov 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yana ZorkinaVladimir Chekhonin
Apr 4, 2021·Nanomaterials·Adelina-Gabriela NiculescuAlexandru Mihai Grumezescu
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fakhara SabirIldikó Csóka
Apr 30, 2021·Methods : a Companion to Methods in Enzymology·Adelina-Gabriela NiculescuAlexandru Mihai Grumezescu
Jun 18, 2021·Lab on a Chip·Priscilla C O S FirminoLucimara G de la Torre
Oct 28, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Kwang Joo KwakL James Lee
Jun 6, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Tatsuya ShimaKazushi Kinbara
Mar 10, 2015·Molecular Pharmaceutics·Yi CuiJoseph Irudayaraj
Feb 12, 2018·ACS Biomaterials Science & Engineering·Selya Amrani, Maryam Tabrizian
Jul 13, 2019·ACS Nano·Ahanjit Bhattacharya, Neal K Devaraj
Nov 1, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Julio H K RozenfeldAna M Carmona-Ribeiro

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