Microfluidic Packaging Integration with Electronic-Photonic Biosensors Using 3D Printed Transfer Molding.

Biosensors
Christos AdamopoulosMekhail Anwar

Abstract

Multiplexed sensing in integrated silicon electronic-photonic platforms requires microfluidics with both high density micro-scale channels and meso-scale features to accommodate for optical, electrical, and fluidic coupling in small, millimeter-scale areas. Three-dimensional (3D) printed transfer molding offers a facile and rapid method to create both micro and meso-scale features in complex multilayer microfluidics in order to integrate with monolithic electronic-photonic system-on-chips with multiplexed rows of 5 μm radius micro-ring resonators (MRRs), allowing for simultaneous optical, electrical, and microfluidic coupling on chip. Here, we demonstrate this microfluidic packaging strategy on an integrated silicon photonic biosensor, setting the basis for highly multiplexed molecular sensing on-chip.

References

Jan 9, 2003·Journal of the American Chemical Society·Hongkai WuGeorge M Whitesides
Sep 22, 2005·Lab on a Chip·Chu-Ya YangCarlo D Montemagno
Apr 23, 2008·Current Protocols in Protein Science·Laure Jason-MollerJoAnne Bruno
Mar 6, 2010·Nature Protocols·Dong QinGeorge M Whitesides
Aug 11, 2010·Biomicrofluidics·James Friend, Leslie Yeo
Nov 28, 2013·Lab on a Chip·Germán CominaDaniel Filippini
Jul 15, 2016·Optics Express·Jonas FlueckigerKaren C Cheung
Feb 28, 2018·Advanced Materials·Sherjeel M KhanMuhammad M Hussain

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