Microfluidic sorting system based on optical waveguide integration and diode laser bar trapping

Lab on a Chip
Robert W ApplegateAli A Said

Abstract

Effective methods for manipulating, isolating and sorting cells and particles are essential for the development of microfluidic-based life science research and diagnostic platforms. We demonstrate an integrated optical platform for cell and particle sorting in microfluidic structures. Fluorescent-dyed particles are excited using an integrated optical waveguide network within micro-channels. A diode-bar optical trapping scheme guides the particles across the waveguide/micro-channel structures and selectively sorts particles based upon their fluorescent signature. This integrated detection and separation approach streamlines microfluidic cell sorting and minimizes the optical and feedback complexity commonly associated with extant platforms.

References

Nov 5, 1999·Nature Biotechnology·A Y FuS R Quake
Aug 26, 2000·Current Opinion in Chemical Biology·R P Hertzberg, A J Pope
Jun 29, 2001·Nature·S TakayamaG M Whitesides
May 22, 2002·BioTechniques·Kenneth E PierceLawrence J Wangh
Dec 7, 2002·Biotechnology Progress·John OakeyDavid W M Marr
Jan 6, 2004·Nature Materials·Jesper Glückstad
Jun 5, 2004·Journal of Nanobiotechnology·Kazunori TakahashiKenji Yasuda
Sep 24, 2004·Nature·David Erhardt
Nov 1, 1996·Optics Letters·K M DavisK Hirao
Dec 15, 1987·Applied Optics·T N BuicanJ C Martin
Dec 1, 1998·Analytical Chemistry·D C DuffyG M Whitesides

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Citations

Apr 9, 2010·Analytical Chemistry·John OakeyMehmet Toner
Apr 3, 2008·Journal of the Royal Society, Interface·Hu Zhang, Kuo-Kang Liu
Jul 21, 2011·Se pu = Chinese journal of chromatography·Haifang LiJin-Ming Lin
Feb 15, 2012·Applied Physics Letters·John LeblancManish J Butte
Aug 15, 2014·Lab on a Chip·Moez HaquePeter R Herman
Nov 22, 2008·Lab on a Chip·Chia-Hsien HsuMehmet Toner
Mar 12, 2010·Lab on a Chip·Allen H J Yang, David Erickson
Jul 24, 2012·Lab on a Chip·Koji Sugioka, Ya Cheng
Apr 5, 2014·Current Opinion in Chemical Engineering·Emily L Jackson, Hang Lu
Mar 5, 2007·Optics Express·Sean J HartTomasz A Leski
Jun 6, 2009·Journal of Chromatography. a·Hisham MohamedMichele Caggana
Feb 24, 2016·RSC Advances·A KasukurtiD W M Marr
Jan 5, 2010·Mechanics Research Communications·Hideaki Tsutsui, Chih-Ming Ho
Jul 19, 2008·Biosensors & Bioelectronics·Yen-Heng Lin, Gwo-Bin Lee
Jan 9, 2009·Electrophoresis·Alexandr Jonás, Pavel Zemánek
Aug 8, 2006·Current Opinion in Biotechnology·Joel Voldman
Nov 14, 2015·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Kevin B RothDavid W M Marr
Mar 18, 2011·Biomedical Optics Express·Allison SchaapThomas Rohrlack
Mar 24, 2015·Biomedical Optics Express·K B RothD W M Marr
Jun 13, 2014·Optics Express·Julien BurginJean-Pierre Delville
Feb 12, 2014·Optics Express·Kaelyn D LeakeHolger Schmidt
Aug 5, 2014·Optics Express·Giorgio VolpeSylvain Gigan
Jun 7, 2011·Optics Express·A KasukurtiD W M Marr
Feb 27, 2008·Acta Biologica Hungarica·H I KireiP Ormos
Nov 26, 2013·Biophysical Journal·Tobias SawetzkiDavid W M Marr
Feb 12, 2009·Lab on a Chip·Rebeca Martinez VazquezGiulio Cerullo
Mar 7, 2014·Integrative Biology : Quantitative Biosciences From Nano to Macro·Laura M McLaughlinDenise M Monack
Jan 30, 2008·Nanotechnology·Allen H J Yang, David Erickson
Feb 1, 2018·Proceedings of the Institution of Mechanical Engineers. Part C. Journal of Mechanical Engineering Science·Jifu TanYaling Liu

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