Microfluidic technology: an economical and versatile approach for the synthesis of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET)

Bioorganic & Medicinal Chemistry Letters
Vincent R BouvetFrank Wuest

Abstract

A new synthesis of O-(2-[(18)F]fluoroethyl)-L-tyrosine [(18)F]FET was developed using a NanoTek® microfluidic synthesis system (Advion BioSciences, Inc.). Optimal reaction conditions were studied through screening different reaction parameters like temperature, flow rate, reaction time, concentration of the labeling precursor, and the applied volume ratio between the labeling precursor and [(18)F]fluoride. [(18)F]FET was obtained after HPLC purification with 50% decay-corrected radiochemical yield starting from as little as 40 μg of labeling precursor. Small animal PET studies in EMT-6 tumor bearing mice showed radioactivity accumulation in the tumor (SUV(60min) 1.21±0.2) resulting in an slightly increasing tumor-to-muscle ratio over time.

References

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Citations

Mar 8, 2013·Future Medicinal Chemistry·Robin Fortt, Antony Gee
Jul 26, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Christian RenschBjörn Wängler
May 21, 2013·Nuclear Medicine and Biology·Giancarlo PascaliPiero A Salvadori
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Sep 6, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Karla-Anne KnappH Charles Manning
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Mar 10, 2018·Journal of Labelled Compounds & Radiopharmaceuticals·Ren IwataKazuhiko Yanai
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Dec 8, 2020·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Aixia SunGanghua Tang

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