Microfluidic technology enhances the potential of human pluripotent stem cells

Biochemical and Biophysical Research Communications
Camilla LuniNicola Elvassore

Abstract

Since the discovery of human somatic cell reprogramming, human induced pluripotent stem cells (hiPSC) have been increasingly recognized as the landmark for development of organs-on-chip. hiPSCs show a remarkable plasticity that is related to their ability to promptly respond to the surrounding environment. In vitro, the soluble culture microenvironment, with its critical balance between exogenous and cell-secreted factors, plays a great role in inducing hiPSC response, for both preserving pluripotency and controlling differentiation stages. Exploring the complexity of hiPSC microenvironment requires new experimental tools, as a tight control is limited within conventional culture dishes. Microfluidic technology is particularly attractive in hiPSC research because of its ability to mimic specific environmental cues by accurate control of soluble factors with high spatiotemporal resolution and in a high-throughput fashion. In this review, we highlight recent progress in hiPSC research enabled by microfluidic technology as well as new emerging scenarios.

References

Jul 28, 2006·Nature·George M Whitesides
Feb 3, 2007·Annual Review of Biophysics and Biomolecular Structure·Jessica Melin, Stephen R Quake
Jun 1, 2007·Lab on a Chip·Elisa FigalloGordana Vunjak-Novakovic
Sep 20, 2008·Nature Reviews. Genetics·Joseph S TakahashiErin L McDearmon
Jun 6, 2009·Lab on a Chip·Luis Gerardo Villa-DiazGary Daniel Smith
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kazuhiro YagitaYasuo Uchiyama
May 5, 2011·Nature Cell Biology·Huck-Hui Ng, M Azim Surani
Jun 10, 2011·Nature·Sirio DupontStefano Piccolo
Jul 7, 2011·Biotechnology and Bioengineering·Drew TitmarshJustin Cooper-White
Aug 3, 2011·Proceedings of the National Academy of Sciences of the United States of America·Adam K WhiteCarl L Hansen
Jan 6, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Susi ZattiNicola Elvassore
Apr 9, 2013·Nature Methods·Ankur SinghAndrés J García
Jun 12, 2013·Cell Stem Cell·Sandra J Engle, Dinesh Puppala
Jul 3, 2013·Biotechnology Journal·Drew M TitmarshJustin J Cooper-White
Oct 22, 2013·Nature Materials·Timothy L DowningSong Li
Nov 14, 2013·Biotechnology and Bioengineering·Ryosuke YoshimitsuToshiyuki Kanamori
Feb 4, 2014·Current Opinion in Biotechnology·Camilla LuniNicola Elvassore
Feb 18, 2014·Lab on a Chip·Alexandre BenedettoGuillaume Charras
Jun 30, 2014·Nature Methods·Aryeh WarmflashAli H Brivanlou
Oct 29, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Tüzer Kalkan, Austin Smith
Jun 2, 2015·Nature Methods·Giovanni G GiobbeNicola Elvassore

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Citations

Nov 11, 2016·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Valentina ScattoliniGian Paolo Fadini
Jul 29, 2017·Lab on a Chip·Yujuan ZhuJianhua Qin
Jan 1, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Nureddin AshammakhiAnwarul Hasan
Sep 15, 2017·Advanced Healthcare Materials·Armin GerailiAmir Sanati-Nezhad
Feb 28, 2019·Nature Protocols·Onelia GaglianoNicola Elvassore
Dec 15, 2018·Biotechnology Progress·Alice ZosoNicola Elvassore
Mar 31, 2021·Scientific Reports·Eleonora De VitisAlessandro Polini

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