Microfluidic Valves Made From Polymerized Polyethylene Glycol Diacrylate

Sensors and Actuators. B, Chemical
Chad I RogersAdam T Woolley

Abstract

Pneumatically actuated, non-elastomeric membrane valves fabricated from polymerized polyethylene glycol diacrylate (poly-PEGDA) have been characterized for temporal response, valve closure, and long-term durability. A ~100 ms valve opening time and a ~20 ms closure time offer valve operation as fast as 8 Hz with potential for further improvement. Comparison of circular and rectangular valve geometries indicates that the surface area for membrane interaction in the valve region is important for valve performance. After initial fabrication, the fluid pressure required to open a closed circular valve is ~50 kPa higher than the control pressure holding the valve closed. However, after ~1000 actuations to reconfigure polymer chains and increase elasticity in the membrane, the fluid pressure required to open a valve becomes the same as the control pressure holding the valve closed. After these initial conditioning actuations, poly-PEGDA valves show considerable robustness with no change in effective operation after 115,000 actuations. Such valves constructed from non-adsorptive poly-PEGDA could also find use as pumps, for application in small volume assays interfaced with biosensors or impedance detection, for example.

References

Sep 22, 2005·Lab on a Chip·William H Grover, Richard A Mathies
Aug 1, 2006·American Journal of Obstetrics and Gynecology·Carlos J VanceSteven W Graves
Jul 23, 2008·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·J-K LeeL F Mockros
May 14, 2010·Analytical Chemistry·Arun AroraAndreas Manz
Nov 16, 2010·American Journal of Obstetrics and Gynecology·M Sean EsplinUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
May 14, 2011·Advanced Materials·Luc GervaisEmmanuel Delamarche
Jan 20, 2012·Analytical Chemistry·Jungkyu KimRichard A Mathies
Feb 22, 2012·Lab on a Chip·Curtis D ChinSamuel K Sia
Sep 22, 2012·Journal of Chromatography. a·Pamela N NgeAdam T Woolley
Nov 13, 2012·Analytical Chemistry·Michelle L KovarikNancy L Allbritton
Feb 16, 2013·Chemical Reviews·Pamela N NgeAdam T Woolley
Jun 8, 2013·Lab on a Chip·Katharina SchimekReyk Horland

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Citations

Jan 23, 2015·Biomicrofluidics·Chad I RogersGregory P Nordin
Feb 9, 2016·Angewandte Chemie·Anthony K AuAlbert Folch
Nov 6, 2015·Analytical and Bioanalytical Chemistry·V SahoreA T Woolley
May 25, 2016·Lab on a Chip·Arturo UrriosAlbert Folch
Mar 20, 2018·Lab on a Chip·Yuan-Sheng LeeAlbert Folch
Nov 15, 2018·Micromachines·Juan Eduardo Sosa-HernándezHafiz M N Iqbal
Jun 6, 2019·Annual Review of Biomedical Engineering·Arman NaderiAlbert Folch
Nov 7, 2019·Micromachines·Jia Ming ZhangHuiling Duan
Nov 23, 2018·Sensors·Elingas CekasSigita Ponelyte Urbaite
Jun 4, 2020·Advanced Materials Technologies·Alexandra P KuoAlbert Folch
Jun 1, 2016·Lab on a Chip·Hua GongGregory P Nordin
Jan 23, 2018·Lab on a Chip·Hua GongGregory P Nordin
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Max J MännelJulian Thiele
Sep 10, 2019·ACS Applied Materials & Interfaces·Xuemin WangCraig A Aspinwall

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