Microfracture combined with osteochondral paste implantation was more effective than microfracture alone for full-thickness cartilage repair.

Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA
Linzi XingYan Xu

Abstract

The aim of this study was to evaluate whether the microfracture combined with osteochondral paste implantation could promote the quality of the regenerated tissue in the knee joints of rabbits. Sixty-six New Zealand white rabbits were used. Bilateral knee joints from the same rabbit were randomly divided into experimental group and microfracture group. An articular cartilage defect was established in the femoral trochlear groove. In the experimental group, the defect was microfractured and covered with osteochondral paste harvested from the intercondylar notch. The regenerated tissues were harvested for gross morphology, histology, biochemistry and gene expression analysis at 4, 8 and 12 weeks postoperatively. The regenerated tissue had a slowly mature process in both groups. At 12 weeks, the regenerated tissue in the experimental group appeared much more thicker and white with higher percentages of defect filling macroscopically. In histology, the experimental group found a majority of hyaline-like regenerate tissue with intense Safranin-O and collagen type II staining, while fibrocartilage-like tissue was mostly seen in the microfracture group with poor Safranin-O and collagen type II staining. The experimental group had high...Continue Reading

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Citations

Oct 3, 2014·Arthroscopy Techniques·Bryan D HaughomShane J Nho
Dec 3, 2014·The Knee·Kevin R StoneThomas J Turek
May 15, 2015·Journal of Orthopaedic Surgery and Research·Sandra GeraghtyAlla Danilkovitch
Aug 1, 2015·Sports Medicine and Arthroscopy Review·Alan M Hirahara, Kenneth W Mueller
Oct 25, 2014·Journal of Tissue Engineering·Seog-Jin SeoHae-Won Kim
Oct 4, 2016·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Kevin R StoneThomas J Turek
Jan 28, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jun LiuXingdong Zhang
Feb 27, 2021·Frontiers in Cell and Developmental Biology·Taylor MustapichDaniel A Grande

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