Microglia: A Potential Drug Target for Traumatic Axonal Injury.

Neural Plasticity
Xin HuangLiang Wen

Abstract

Traumatic axonal injury (TAI) is a major cause of death and disability among patients with severe traumatic brain injury (TBI); however, no effective therapies have been developed to treat this disorder. Neuroinflammation accompanying microglial activation after TBI is likely to be an important factor in TAI. In this review, we summarize the current research in this field, and recent studies suggest that microglial activation plays an important role in TAI development. We discuss several drugs and therapies that may aid TAI recovery by modulating the microglial phenotype following TBI. Based on the findings of recent studies, we conclude that the promotion of active microglia to the M2 phenotype is a potential drug target for the treatment of TAI.

References

Apr 1, 1974·Journal of Neurology, Neurosurgery, and Psychiatry·J M Clark
Apr 1, 1997·Journal of Clinical Pathology·J F Geddes
Nov 5, 2003·FEBS Letters·Steven W PaughSarah Spiegel
Nov 16, 2004·Forensic Science International : Synergy·S M GentlemanJ A R Nicoll
May 7, 2005·Acta Neuropathologica·Alejandra C Rodriguez-PaezHelen M Bramlett
Aug 16, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·I YatsivE Shohami
Nov 7, 2007·Journal of Neuropathology and Experimental Neurology·Brian Joseph KelleyJohn Theodore Povlishock
Nov 16, 2007·Journal of Neurotrauma·Kumi Nagamoto-CombsColin K Combs
Jun 7, 2008·Journal of Neurotrauma·Tomohiro Matsui, Takahiro Kakeda
Aug 12, 2008·Brain : a Journal of Neurology·A Mackay-SimT Geraghty
Sep 3, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Na'ama A SheinEsther Shohami
Dec 1, 2009·Acta Neuropathologica·Swati B NaphadeJeff Kuret
Jun 18, 2010·Canadian Journal of Physiology and Pharmacology·Nader ShahrokhiNouzar Nakhaee
Apr 30, 2011·Physiological Reviews·Helmut KettenmannAlexei Verkhratsky
Jun 29, 2011·Annals of Neurology·Anil F RamlackhansinghDavid J Sharp
Jul 12, 2011·Expert Opinion on Therapeutic Targets·Emanuela Esposito, Salvatore Cuzzocrea
Jan 31, 2012·Experimental Neurology·Victoria E JohnsonDouglas H Smith
Aug 16, 2012·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Chunlei TianZhixian Wan
Dec 1, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Sonja Johann, Cordian Beyer
Dec 13, 2012·Neuropathology and Applied Neurobiology·C SmithJ A R Nicoll
Dec 28, 2012·Neurocritical Care·Bo WangDaniel T Laskowitz
Feb 1, 2013·Brain : a Journal of Neurology·Victoria E JohnsonWilliam Stewart
Feb 20, 2013·Therapeutic Hypothermia and Temperature Management·Helen M Bramlett, W Dalton Dietrich

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

© 2021 Meta ULC. All rights reserved