Microglia and astroglia prevent oxidative stress-induced neuronal cell death: implications for aceruloplasminemia

Biochimica Et Biophysica Acta
Satoru OshiroKazuyuki Nakajima

Abstract

We partially characterized the transferrin-independent iron uptake (Tf-IU) of neuronal and glial cells in the previous report. In the present study, we further examined a mechanism of which glial cells protect neuronal cells against iron stress using neuron-microglia (N-MG) and neuron-astrocyte (N-AS) co-cultures. When each solely purified cell was treated with iron citrate, cell death occurred in N and MG. However, AS proliferated under the same condition. Both N-MG and N-AS co-cultures were effective in resistance to excessive iron. The total and specific Tf-IU activities of N-MG co-cultures similar to those of N did not increase in a density-dependent manner. Contrarily, the total activity of AS was extremely high and the specific activity was extremely low as a result of proliferation. Regarding of effect of co-cultures on H(2)O(2)-induced cell death, N-MG co-cultures were less effective, but N-AS co-cultures were more effective in protecting N from the oxidative stress. These results suggest that N-MG co-cultures suppress the Tf-IU and N-AS co-cultures stimulate AS proliferation to protect neuronal cells. Brain cells from aceruloplasminemia with mutations in the ceruloplasmin gene take up iron by Tf-IU. Therefore, the diff...Continue Reading

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Citations

May 1, 2010·Neurotoxicity Research·Glenda M BishopStephen R Robinson
Oct 21, 2011·Advances in Pharmacological Sciences·Satoru OshiroMasataka Kikuchi
Oct 9, 2012·Prostaglandins & Other Lipid Mediators·Rui LiDao Wen Wang
Aug 5, 2008·Neurobiology of Disease·Shannon L Rhodes, Beate Ritz
Apr 4, 2016·Molecular Neurobiology·Hong JiangJunxia Xie
Mar 5, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Piera SozioAntonio Di Stefano
Sep 12, 2009·Journal of Neuroscience Research·Ketki TulpuleRalf Dringen
Dec 15, 2010·Rejuvenation Research·Maximus V Peto
Mar 19, 2019·Frontiers in Neuroscience·Alain NdayisabaGregor K Wenning
Nov 22, 2013·Biochemical Society Transactions·Michaela C Hohnholt, Ralf Dringen

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