Microglia-associated granule cell death in the normal adult dentate gyrus.

Brain Structure & Function
Charles E RibakIgor Spigelman

Abstract

Microglial cells are constantly monitoring the central nervous system for sick or dying cells and pathogens. Previous studies showed that the microglial cells in the dentate gyrus have a heterogeneous morphology with multipolar cells in the hilus and fusiform cells apposed to the granule cell layer both at the hilar and at the molecular layer borders. Although previous studies showed that the microglia in the dentate gyrus were not activated, the data in the present study show dying granule cells apposed by Iba1-immunolabeled microglial cell bodies and their processes both at hilar and at molecular layer borders of the granule cell layer. Initially, these Iba1-labeled microglial cells surround individual, intact granule cell bodies. When small openings in the plasma membrane of granule cells are observed, microglial cells are apposed to these openings. When larger openings in the plasma membrane occur at this site of apposition, the granule cells display watery perikaryal cytoplasm, watery nucleoplasm and damaged organelles. Such morphological features are characteristic of neuronal edema. The data also show that following this localized disintegration of the granule cell's plasma membrane, the Iba1-labeled microglial cell body...Continue Reading

References

Aug 1, 1995·Neuropathology and Applied Neurobiology·J GehrmannG W Kreutzberg
Feb 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·C S ColwellM S Levine
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·G KempermannF H Gage
Nov 24, 1998·Hippocampus·I DalmauB Castellano
Jun 24, 1999·The Journal of Comparative Neurology·F de BilbaoM Dubois-Dauphin
Feb 11, 2000·Toxicologic Pathology·L C Schmued, K J Hopkins
Jun 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·U A HirtM Leist
Jun 15, 2001·The Journal of Comparative Neurology·H A Cameron, R D McKay
Mar 5, 2002·Nature·Henriette van PraagFred H Gage
Dec 22, 2004·The European Journal of Neuroscience·Irmgard AmreinHans-Peter Lipp
May 17, 2005·Nature Neuroscience·Dimitrios DavalosWen-Biao Gan
Jan 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chunmei ZhaoFred H Gage
Jan 18, 2006·Hippocampus·Brian R Christie, Heather A Cameron
Jan 18, 2006·Hippocampus·Linda S Overstreet-Wadiche, Gary L Westbrook
Nov 3, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·James B AckmanJoseph J LoTurco
May 9, 2007·Nature Neuroscience·Nicolas ToniFred H Gage
May 19, 2007·The European Journal of Neuroscience·Diego A LaplagneAlejandro F Schinder
Oct 24, 2007·Trends in Neurosciences·Knut BiberHendrikus W G M Boddeke
Jul 16, 2008·Nature Neuroscience·Nicolas ToniAlejandro F Schinder

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Citations

Mar 2, 2012·Neuron Glia Biology·José L Marín-TevaJulio Navascués
Nov 13, 2012·PloS One·Francisco J Sancho-BielsaCarlos López-García
Sep 15, 2010·Brain Research Reviews·Maira L ForestiLee A Shapiro
Oct 23, 2010·Glia·Ida A K NilssonJeanette E Johansen
Oct 8, 2014·Physiological Reviews·James B AimoneFred H Gage
Feb 26, 2019·Frontiers in Neuroscience·Ida A K Nilsson
Nov 7, 2019·Glia·Giorgia FattoriniFiorenzo Conti

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Methods Mentioned

BETA
electron microscopy
dissecting
confocal microscopy
light microscopy

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