Microglia from the developing rat medial septal area can affect cholinergic and GABAergic neuronal differentiation in vitro

Neuroscience
I E Mazzoni, R L Kenigsberg

Abstract

The normal development of the central nervous system is regulated by glia. In this regard, we have reported that astrocytes, stimulated by epidermal growth factor or transforming growth factor alpha, suppress the biochemical differentiation of rat medial septal cholinergic neurons in vitro, as evidenced by a decrease in choline acetyltransferase activity. In this study, we found that, in contrast to astrocytes, microglia enhance rather than suppress this aspect of cholinergic cell expression. When in excess, microglia can revert the effects of epidermal growth factor on the septal cholinergic neurons without altering the astroglial proliferative response to this growth factor. In the absence of growth factors or other glial cell types, microglia increase choline acetyltransferase activity above control levels and thus, may be a source of cholinergic differentiating activity. The increase in enzyme activity induced by microglia is rapid in onset, detected as early as 2 h after their addition to the septal neurons and maintained up to six or seven days in vitro. Furthermore, in the absence or presence of other glial cell types, microglia also influence septal GABAergic neurons by significantly increasing glutamate decarboxylase a...Continue Reading

References

Jan 1, 1992·Brain Research. Brain Research Reviews·W E Thomas
Feb 25, 1991·Neuroscience Letters·M ShimojoS Kohsaka
Nov 1, 1986·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H TagoT Maeda
Jun 1, 1988·Trends in Neurosciences·V H Perry, S Gordon
Jul 1, 1989·Neurochemical Research·G Bruce, L B Hersh
May 1, 1989·Developmental Biology·M MallatA Prochiantz
May 12, 1986·Nucleic Acids Research·D R CohenI G Young
Sep 1, 1987·European Journal of Immunology·K FreiA Fontana
Jun 1, 1980·The Journal of Cell Biology·K D McCarthy, J de Vellis
Jan 19, 1984·Nature·M C FungI G Young
Aug 1, 1995·Journal of Neuroscience Research·Y KonishiT Tabira
Jul 1, 1995·Journal of Neuroimmunology·K AppelP J Gebicke-Haerter
Mar 1, 1994·Journal of Neuroimmunology·P J Gebicke-HaerterM Berger
Aug 1, 1993·Neuroscience Research·K Nakajima, S Kohsaka
Jul 1, 1993·Journal of Chemical Neuroanatomy·W J Streit
Jan 1, 1993·Glia·R B BanatiG W Kreutzberg
Jan 1, 1993·Glia·P L McGeerE G McGeer

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Citations

Aug 11, 2000·Microscopy Research and Technique·M CaleroJ Ghiso
Dec 14, 2002·Brain Research. Developmental Brain Research·Chao Chuan WangChen Yuan Wen
Oct 7, 1998·Progress in Neurobiology·M A Cuadros, J Navascués
Sep 8, 2000·Neuroreport·R Suzuki, A H Dickenson
Jul 24, 2004·Anesthesia and Analgesia·Philip J Siddall, Michael J Cousins
Dec 17, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Lorena López-GriegoJorge Morales-Montor
Oct 31, 2002·Reviews in the Neurosciences·Elisabetta Polazzi, Antonio Contestabile
Oct 24, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·G Miller Jonakait
Mar 10, 1999·Methods : a Companion to Methods in Enzymology·K Dobrenis

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