Microglia Function on Precursor Cells in the Adult Hippocampus and Their Responsiveness to Serotonin Signaling.

Frontiers in Cell and Developmental Biology
Andrei TurkinFriederike Klempin

Abstract

Microglia are the resident immune cells of the adult brain that become activated in response to pathogen- or damage-associated stimuli. The acute inflammatory response to injury, stress, or infection comprises the release of cytokines and phagocytosis of damaged cells. Accumulating evidence indicates chronic microglia-mediated inflammation in diseases of the central nervous system, most notably neurodegenerative disorders, that is associated with disease progression. To understand microglia function in pathology, knowledge of microglia communication with their surroundings during normal state and the release of neurotrophins and growth factors in order to maintain homeostasis of neural circuits is of importance. Recent evidence shows that microglia interact with serotonin, the neurotransmitter crucially involved in adult neurogenesis, and known for its role in antidepressant action. In this chapter, we illustrate how microglia contribute to neuroplasticity of the hippocampus and interact with local factors, e.g., BDNF, and external stimuli that promote neurogenesis. We summarize the recent findings on the role of various receptors in microglia-mediated neurotransmission and particularly focus on microglia's response to serotoni...Continue Reading

References

Apr 30, 2003·The Journal of Comparative Neurology·Alexandre G DayerHeather A Cameron
Oct 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Christine T EkdahlOlle Lindvall
Nov 15, 2003·Science·Michelle L MonjeTheo D Palmer
Nov 18, 2003·Nature Reviews. Neuroscience·Patricia GasparLuc Maroteaux
Nov 19, 2003·The Journal of Comparative Neurology·Golo KronenbergGerd Kempermann
Mar 12, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Guido J BurbachThomas Deller
Mar 11, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Angela M FlodenColin K Combs
Jul 5, 2005·Neuropharmacology·Cécile MahéPhilippe Schoeffter
Sep 4, 2007·Progress in Brain Research·Mark Pickering, John J O'Connor
Oct 2, 2007·Trends in Neurosciences·Jennifer M Pocock, Helmut Kettenmann
Oct 16, 2008·Journal of Neuroscience Research·Chae-Moon LimJa-Kyeong Lee
Dec 17, 2008·Annals of the New York Academy of Sciences·Mark P Mattson
Aug 20, 2010·Frontiers in Molecular Neuroscience·Friederike KlempinGerd Kempermann
Oct 5, 2010·Cell Stem Cell·Amanda SierraMirjana Maletic-Savatic
Apr 30, 2011·Physiological Reviews·Helmut KettenmannAlexei Verkhratsky
Jul 23, 2011·Science·Rosa C PaolicelliCornelius T Gross
Dec 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Olivier PascualAlain Bessis
Dec 27, 2011·Brain, Behavior, and Immunity·Grietje KrabbeHelmut Kettenmann
Jul 25, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Laurent Descarries, Mustaph Riad
Jan 29, 2013·Nature Neuroscience·György Buzsáki, Edvard I Moser
Jan 29, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mateo de las Casas-EngelAngel L Corbí
Apr 3, 2013·Current Protein & Peptide Science·Akio Suzumura
Apr 20, 2013·Nature Immunology·Jörg J Goronzy, Cornelia M Weyand
May 10, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Friederike KlempinNatalia Alenina
Oct 4, 2013·Neural Plasticity·Francesco Ferrini, Yves De Koninck
Nov 28, 2013·PloS One·So-Hee LimJae-Ran Lee

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