Microglia in the spinal cord and neuropathic pain

Journal of Diabetes Investigation
Makoto Tsuda

Abstract

In contrast to physiological pain, pathological pain is not dependent on the presence of tissue-damaging stimuli. One type of pathological pain - neuropathic pain - is often a consequence of nerve injury or of diseases such as diabetes. Neuropathic pain can be agonizing, can persist over long periods and is often resistant to known painkillers. A growing body of evidence shows that many pathological processes within the central nervous system are mediated by complex interactions between neurons and glial cells. In the case of painful peripheral neuropathy, spinal microglia react and undergo a series of changes that directly influence the establishment of neuropathic pain states. After nerve damage, purinergic P2X4 receptors (non-selective cation channels activated by extracellular adenosine triphosphate) are upregulated in spinal microglia in a manner that depends on the transcription factors interferon regulatory factor 8 and 5, both of which are expressed in microglia after peripheral nerve injury. P2X4 receptor expression on the cell surface of microglia is also regulated at the post-translational level by signaling from CC chemokine receptor chemotactic cytokine receptor 2. Furthermore, spinal microglia in response to extra...Continue Reading

References

Sep 1, 1988·Diabetic Medicine : a Journal of the British Diabetic Association·J P O'HareR J Corrall
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·K D LustigD Julius
Jun 17, 1999·Lancet·C J Woolf, R J Mannion
Jun 10, 2000·Science·C J Woolf, M W Salter
Jul 31, 2001·Trends in Neurosciences·L R WatkinsS F Maier
Oct 31, 2002·Nature Neuroscience·Joachim Scholz, Clifford J Woolf
May 8, 2003·The Journal of Pharmacology and Experimental Therapeutics·Vasudeva RaghavendraJoyce A DeLeo
May 14, 2004·Journal of the Neurological Sciences·Nigel A Calcutt
Jan 26, 2005·Trends in Neurosciences·Makoto TsudaMichael W Salter
Feb 11, 2005·Journal of the Peripheral Nervous System : JPNS·Peter D J ThorntonMark B Plenderleith
Apr 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Flobert Y TangaJoyce A DeLeo
May 17, 2005·Nature Neuroscience·Dimitrios DavalosWen-Biao Gan
May 19, 2005·The Journal of Clinical Endocrinology and Metabolism·Aaron Vinik
Jul 5, 2005·Nature Reviews. Neuroscience·Fabien MarchandStephen B McMahon
Apr 12, 2006·Journal of Neurochemistry·Minoru NaritaTsutomu Suzuki
Apr 21, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bryan C Hains, Stephen G Waxman
Aug 4, 2006·Nature·Baljit S Khakh, R Alan North
Aug 26, 2006·Nature Clinical Practice. Neurology·Ralf Baron
Mar 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Peng ZhaoBryan C Hains
Apr 12, 2007·The European Journal of Neuroscience·Hiroshi IkedaKazuyuki Murase
Jun 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Anna K ClarkMarzia Malcangio
Oct 18, 2007·Journal of Cell Science·Omar S QureshiRuth D Murrell-Lagnado
Oct 30, 2007·Nature Neuroscience·Joachim Scholz, Clifford J Woolf
Nov 2, 2007·Molecular Pain·Ru-Rong Ji, Marc R Suter
Nov 9, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ji ZhangSerge Rivest

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Citations

Aug 9, 2016·Expert Review of Neurotherapeutics·Arianna Scuteri, Guido Cavaletti
Jul 31, 2016·Experimental Physiology·Nikita N BurkeTuan Trang
Oct 27, 2017·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A HorstW A Partata
Nov 18, 2017·PLoS Neglected Tropical Diseases·Caroline IsaacLaure Guenin-Macé
May 11, 2017·Journal of Cellular Physiology·Maria Caterina PaceCaterina Aurilio
Nov 20, 2018·Molecular Pain·Kimberly E StephensYun Guan
May 17, 2019·Clinical Epigenetics·Simin Tang HanbingWang
Dec 14, 2019·Journal of Molecular Neuroscience : MN·Aitao WangXingsheng Zhao
Jul 26, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Daniela ImpellizzeriRosanna Di Paola
Jun 24, 2020·Journal of Leukocyte Biology·Idy H T HoXiaodong Liu
Jul 8, 2020·International Journal of Molecular Sciences·Tzu-Hsuan Wei, Ching-Liang Hsieh
Sep 10, 2020·Molecular Neurobiology·Simin TangJun Zhou
Jan 26, 2020·Journal of Clinical Medicine·Yuhua YinDong-Woon Kim
Jul 6, 2019·Journal of Diabetes and Metabolic Disorders·Che Aishah Nazariah IsmailIdris Long
Jun 21, 2016·Journal of Neuroscience Research·Heng YanXin Zhao
Oct 11, 2017·Frontiers in Pharmacology·Geoffrey Burnstock
Jul 2, 2020·Cells·Mohammed M H AsiriJo W M Höppener
Aug 14, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Dario PfyfferPatrick Freund
Jul 31, 2020·International Journal of Molecular Sciences·Ramona D'AmicoRosanna Di Paola
Jul 5, 2016·Journal of Neuroscience Research·Makoto Tsuda
Jul 25, 2018·Scientific Reports·Tomoko SasaguriToshiharu Yasaka
Sep 29, 2020·Annals of Rehabilitation Medicine·Dong Gyu Kwak, Dong Gyu Lee

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