Microglia modulate hippocampal neural precursor activity in response to exercise and aging.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Jana VukovicPerry F Bartlett

Abstract

Exercise has been shown to positively augment adult hippocampal neurogenesis; however, the cellular and molecular pathways mediating this effect remain largely unknown. Previous studies have suggested that microglia may have the ability to differentially instruct neurogenesis in the adult brain. Here, we used transgenic Csf1r-GFP mice to investigate whether hippocampal microglia directly influence the activation of neural precursor cells. Our results revealed that an exercise-induced increase in neural precursor cell activity was mediated via endogenous microglia and abolished when these cells were selectively removed from hippocampal cultures. Conversely, microglia from the hippocampi of animals that had exercised were able to activate latent neural precursor cells when added to neurosphere preparations from sedentary mice. We also investigated the role of CX(3)CL1, a chemokine that is known to provide a more neuroprotective microglial phenotype. Intraparenchymal infusion of a blocking antibody against the CX(3)CL1 receptor, CX(3)CR1, but not control IgG, dramatically reduced the neurosphere formation frequency in mice that had exercised. While an increase in soluble CX(3)CL1 was observed following running, reduced levels of t...Continue Reading

Citations

Jan 23, 2013·Immunology and Cell Biology·Elena ZenaroGabriela Constantin
Aug 29, 2012·Cardiology Research and Practice·Barbara RiegelStephen T Moelter
Dec 5, 2012·PloS One·Daniel G BlackmorePerry F Bartlett
Feb 7, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yukari Shigemoto-MogamiKaoru Sato
Jan 25, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Francesca L'EpiscopoBianca Marchetti
Apr 3, 2014·Trends in Neurosciences·David A Raichlen, Gene E Alexander
Apr 12, 2014·Acta Neuropathologica·Rainer Glass, Michael Synowitz
Sep 24, 2014·Brain Research Bulletin·Peng SuWenjing Luo
Sep 14, 2013·Trends in Cognitive Sciences·Michelle W VossHenriette van Praag
Dec 30, 2014·Stem Cells·Hanadie YousefDavid V Schaffer
Dec 10, 2015·Cellular and Molecular Life Sciences : CMLS·Ricardo C CassilhasMarco Túlio de Mello
Feb 7, 2016·Progress in Neurobiology·Yuanyuan MaGuo-Yuan Yang
Feb 3, 2016·Frontiers in Cellular Neuroscience·Luis Federico BátizUrsula Wyneken
Dec 24, 2015·Neuroscience and Biobehavioral Reviews·Sinéad M Ryan, Yvonne M Nolan
Feb 5, 2013·Brain, Behavior, and Immunity·Lauren L Williamson, Staci D Bilbo
Dec 25, 2012·Trends in Neurosciences·Hiroaki WakeJunichi Nabekura
Sep 19, 2012·Brain, Behavior, and Immunity·Rachel A Kohman, Justin S Rhodes
Dec 24, 2015·Frontiers in Cellular Neuroscience·Nataša Kopitar-Jerala
Nov 4, 2015·Journal of Neuroscience Research·Sabine Ulrike VayMaria Adele Rueger
May 27, 2015·Glia·Kaoru Sato
Nov 28, 2015·Brain, Behavior, and Immunity·Luís Eduardo SantosSergio T Ferreira
Mar 17, 2015·Neuroscience·R M BarrientosS F Maier
Oct 9, 2012·Neuropathology and Applied Neurobiology·D M Norden, J P Godbout
Apr 14, 2016·Stem Cells International·Lachlan HarrisJulian Ik-Tsen Heng
Mar 31, 2016·International Journal of Radiation Oncology, Biology, Physics·Zoey ChengC Shun Wong
Mar 15, 2016·ACS Chemical Neuroscience·Jorge ValeroAmanda Sierra
Oct 7, 2015·Frontiers in Cellular Neuroscience·Michael J StuartBernhard T Baune
May 5, 2016·Stem Cells International·Odette LeiterTara L Walker
Jul 23, 2013·Free Radical Research·Z RadakI Boldogh
Oct 5, 2013·Current Opinion in Neurobiology·Violeta Silva-VargasFiona Doetsch
Feb 13, 2015·Frontiers in Cellular Neuroscience·Lian-Shun ZhengKazunobu Sawamoto
Aug 1, 2014·Frontiers in Cellular Neuroscience·Gregory P MarshallEric D Laywell
Aug 26, 2014·Frontiers in Cellular Neuroscience·Cristina Limatola, Richard M Ransohoff
Jun 10, 2016·Nature Reviews. Neuroscience·Eric S WohlebRonald S Duman
Jun 29, 2016·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Rebecca KleinMichael Schroeter
Nov 5, 2016·Cell·J Tiago GonçalvesFred H Gage

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