Microglia support ATF3-positive neurons following hypoglossal nerve axotomy

Neurochemistry International
Tatsuhide TanakaShigetaka Yoshida

Abstract

Microglia are essential in developmental processes and maintenance of neuronal homeostasis. Experimental axotomy of motor neurons results in neurodegeneration, and microglia in motor nuclei become activated and migrate towards injured neurons. However, whether these activated microglia are protective or destructive to neurons remains controversial. In the present study, we transected the hypoglossal nerve in BALB/c mice, causing activating transcription factor 3 (ATF3) and growth associated protein 43 (GAP43) induction, and partial neuronal death. Inhibition of microglial accumulation by minocycline administration impaired microglial accumulation, decreased GAP43 mRNA expression, and reduced motor neuron survival. Expression of ATF3 contributed to nerve regeneration, and increased within 6 h after axotomy, prior to microglial migration. Further, microglial contact with neuronal cell bodies was associated with neuronal ATF3 expression. Colchicine administration blocked lesion-induced ATF3 transcription in axotomized neurons and microglial accumulation. In addition, perineuronal microglia-derived ciliary neurotrophic factor (CNTF) increased, indicating that perineuronal microglia in the hypoglossal nucleus protect axotomized moto...Continue Reading

Citations

May 20, 2020·Frontiers in Molecular Neuroscience·Francisco J AlvarezTimothy C Cope
Aug 29, 2020·Progress in Neurobiology·Guillaume RastoldoBrahim Tighilet
Jul 3, 2021·International Journal of Molecular Sciences·Núria Gaja-CapdevilaMireia Herrando-Grabulosa

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