Microglial ablation in rats disrupts the circadian system.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Luba SominskySarah J Spencer

Abstract

Microglia, the key neuroimmune cells of the central nervous system, are best known for their function in defending an individual from pathogens and injury. Recent findings, including our own, suggest microglia also have several immune-independent roles, including in regulating satiety, promoting memory, and modifying pain responses. Many of these microglia-associated functions are affected by circadian rhythmicity, thus, varying substantially depending upon the time of day. To gain further insight into this link, we used a Cx3cr1-Dtr transgenic Wistar rat model to acutely deplete microglia and examined if this could lead to a disruption in diurnal temperature, metabolism, and activity measures. We also examined if differences in the physiological rhythms corresponded with changes in the expression of key circadian rhythm-regulating genes and proteins. Our data show that in the absence of microglia there is a pronounced disruption of diurnal rhythms in several domains consistent with a shift toward the inactive phase, in conjunction with changes in circadian rhythm-regulating genes and proteins. These data suggest microglia are involved in the regulation of circadian rhythms and indicate an exciting potential to manipulate these...Continue Reading

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Citations

Dec 29, 2020·Neurochemistry International·Samuel DeurveilherKazue Semba
Apr 10, 2021·Frontiers in Neuroscience·Arthur H Cheng, Hai-Ying Mary Cheng
Aug 3, 2021·Molecular and Cellular Endocrinology·Simin YounesiLuba Sominsky
Aug 8, 2021·International Journal of Molecular Sciences·Mohammed E ChoudhuryJunya Tanaka

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