DOI: 10.1101/19011189Nov 8, 2019Paper

Microglial activation and tau burden predict cognitive decline in Alzheimer's Disease

MedRxiv : the Preprint Server for Health Sciences
M. MalpettiJames B Rowe

Abstract

Tau pathology, neuroinflammation, and neurodegeneration are key aspects of Alzheimer's disease. Understanding whether these features predict cognitive decline, alone or in combination, is crucial to develop new prognostic measures and enhanced stratification for clinical trials. Here, we studied how baseline assessments of in vivo tau pathology (measured by [18F]AV-1451 PET), neuroinflammation (indexed via [11C]PK11195 PET) and brain atrophy (derived from structural MRI) predicted longitudinal cognitive changes in patients with Alzheimer's disease pathology. Twenty-six patients (n=12 with clinically probable Alzheimer's dementia and n=14 with amyloid positive Mild Cognitive Impairment) and 29 healthy controls underwent baseline assessment with [18F]AV-1451 PET, [11C]PK11195 PET, and structural MRI. Cognition was examined annually over the subsequent 3 years using the revised Addenbrooke's Cognitive Examination. Regional grey-matter volumes, [18F]AV-1451 and [11C]PK11195 binding were derived from fifteen temporo-parietal regions characteristically affected by Alzheimer's disease pathology. A Principal Component Analysis (PCA) was used on each imaging modality separately, to identify the main spatial distributions of pathology. A...Continue Reading

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