Microglial activation in early Alzheimer trajectory is associated with higher gray matter volume.

Neurology
Grazia D FemminellaPaul Edison

Abstract

To investigate the influence of microglial activation in the early stages of Alzheimer's disease trajectory, we assessed the relationship between microglial activation and gray matter volume and hippocampal volume in patients with mild cognitive impairment (MCI). In this study, 55 participants (37 with early stages of MCI and 18 controls) underwent [11C]PBR28 PET, a marker of microglial activation; volumetric MRI to evaluate gray matter and hippocampal volumes as well as clinical and neuropsychometric evaluation. [11C]PBR28 VT (volume of distribution) was calculated using arterial input function and Logan graphical analysis. Gray matter volume and hippocampal volumes were calculated from MRI for each participant. Statistical parametric mapping software was used to perform voxel-wise correlations and biological parametric mapping analysis. Amyloid status was assessed using [18F]flutemetamol PET. Higher [11C]PBR28 VT in different cortical areas correlated with higher gray matter volume in both amyloid-positive and -negative MCI. In addition, higher hippocampal volume correlated with higher cortical [11C]PBR28 Logan VT. In this in vivo study, we have demonstrated that microglial activation quantified using [11C]PBR28 PET was assoc...Continue Reading

References

Aug 25, 2004·Journal of Internal Medicine·R C Petersen
Apr 5, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Marc A KrophollerAdriaan A Lammertsma
Apr 16, 2008·Journal of the American Geriatrics Society·Michele L RiesSterling C Johnson
Jul 26, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·P EdisonD J Brooks
Nov 7, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sebastian JimenezJavier Vitorica
Dec 17, 2009·Neurobiology of Aging·Luiz K FerreiraMarcus V Zanetti
Oct 20, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·David R OwenJustin P Rubio
Feb 22, 2012·Alzheimer Disease and Associated Disorders·Liana G ApostolovaPaul M Thompson
May 17, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Maqsood YaqubRonald Boellaard
Jun 20, 2012·Archivum Immunologiae Et Therapiae Experimentalis·Megan M Varnum, Tsuneya Ikezu
Jun 21, 2012·Journal of Neuroscience Research·Juan E Tichauer, Rommy von Bernhardi
Jul 31, 2012·Neurobiology of Aging·Alie SchuitemakerBart N M van Berckel
Jan 3, 2013·Journal of Internal Medicine·G SpulberUNKNOWN dNeuroMed consortium and for the Alzheimer Disease Neuroimaging Initiative
Jan 11, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paul EdisonDavid J Brooks
Jun 19, 2013·Brain : a Journal of Neurology·William C KreislUNKNOWN Biomarkers Consortium PET Radioligand Project Team
Oct 23, 2013·Neuroscience Research·Monty LymanDaqing Ma
Sep 23, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Zhen FanPaul Edison
Dec 3, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·James VarleyPaul Edison
Mar 21, 2015·Lancet Neurology·Michael T HenekaMarkus P Kummer
Apr 5, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Zhen FanPaul Edison
Aug 22, 2015·European Journal of Nuclear Medicine and Molecular Imaging·K CollsteS Cervenka
Jan 20, 2016·Nature Reviews. Neurology·Clifford R JackStephanie J B Vos
Jan 28, 2016·Brain : a Journal of Neurology·Elena Rodriguez-VieitezAgneta Nordberg
Mar 18, 2016·Brain : a Journal of Neurology·Lorraine HamelinUNKNOWN Clinical IMABio3 team
Jul 11, 2016·Brain, Behavior, and Immunity·Elizabeth E Spangenberg, Kim N Green
Jan 27, 2017·Brain : a Journal of Neurology·Zhen FanPaul Edison
Mar 18, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Gourab DattaPaul M Matthews
Oct 8, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Francisco R López-PicónJuha O Rinne
Oct 27, 2017·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Rik VandenbergheAna Graf

❮ Previous
Next ❯

Citations

Sep 12, 2019·Annals of Clinical and Translational Neurology·Nicolas NicastroJohn T O'Brien
Dec 12, 2019·Journal of Neuroinflammation·Fátima Rivera-EscaleraM Kerry O'Banion
Jul 29, 2020·Frontiers in Physiology·Daniela LiccardoAlessandro Cannavo
Apr 22, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Thomas D ParkerJonathan M Schott
Aug 10, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Delphine BocheUNKNOWN MINC Faculty
May 10, 2020·Periodontology 2000·Angela R KamerMony J de Leon
Jun 15, 2020·Neurobiology of Disease·Tina SchwabeHerve Rhinn
Jan 10, 2021·Annals of Clinical and Translational Neurology·Wiesje PelkmansBetty M Tijms
Feb 8, 2020·NeuroImage. Clinical·Nicolas NicastroJohn T O'Brien
Dec 16, 2020·Nature Reviews. Neurology·Fangda Leng, Paul Edison
Jul 15, 2020·Neurobiology of Aging·Nicolas NicastroJohn T O'Brien
Mar 14, 2021·Molecular Neurobiology·Peng-Fei ZhangJin-Tai Yu
Apr 4, 2021·Antioxidants·Eduardo Felipe Alves Fernandes, Dennis Özcelik
Apr 4, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Silvia IngalaUNKNOWN EPAD consortium
Oct 26, 2020·Lancet Neurology·William C KreislRobert B Innis
Jan 26, 2020·Neurobiology of Aging·Lucia BatzuUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Aug 14, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Fabien ChauveauHervé Boutin

❮ Previous
Next ❯

Software Mentioned

Analyze11
SPM12
FreeSurfer
Dryad
biological ( BPM )
MICK
SPM
Siemens
SPSS
MATLAB

Related Concepts

Related Feeds

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Alzheimer's Disease: Microglia

Microglia are a type of glial cell found throughout the brain and spinal cord. Microglia have been found to be associated with Alzheimer's disease development and progression. Here are the latest discoveries pertaining to Alzheimer's disease and microglia.