Microglial Activation Is Modulated by Captopril: in Vitro and in Vivo Studies

Frontiers in Cellular Neuroscience
Keren AsrafSigal Fleisher-Berkovich

Abstract

The renin-angiotensin system (RAS) is an important peripheral system involved in homeostasis modulation, with angiotensin II (Ang II) serving as the main effector hormone. The main enzyme involved in Ang II formation is angiotensin-converting enzyme (ACE). ACE inhibitors (ACEIs) such as captopril (Cap) are predominantly used for the management of hypertension. All of the components of the RAS have also been identified in brain. Centrally located hormones such as Ang II can induce glial inflammation. Moreover, in Alzheimer's disease (AD) models, where glial inflammation occurs and is thought to contribute to the propagation of the disease, increased levels of Ang II and ACE have been detected. Interestingly, ACE overexpression in monocytes, migrating to the brain was shown to prevent AD cognitive decline. However, the specific effects of captopril on glial inflammation and AD remain obscure. In the present study, we investigated the effect of captopril, given at a wide concentration range, on inflammatory mediators released by lipopolysaccharide (LPS)-treated glia. In the current study, both primary glial cells and the BV2 microglial cell line were used. Captopril decreased LPS-induced nitric oxide (NO) release from primary mixe...Continue Reading

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Citations

Dec 24, 2019·Expert Review of Neurotherapeutics·Thibaud LebouvierRégis Bordet
Dec 31, 2019·Protein and Peptide Letters·Victor Teatini RibeiroAna Cristina Simões E Silva
Sep 7, 2018·The Journal of Experimental Medicine·Jacquelyn NestorBetty Diamond
Nov 19, 2019·Neural Plasticity·Benjamin Maïer, Nathalie Kubis
Nov 10, 2020·Journal of Alzheimer's Disease : JAD·Xinquan LiBiao Cai
Oct 30, 2020·Frontiers in Neuroscience·Caglar CosardereliogluPeter M Abadir
Mar 7, 2021·International Journal of Molecular Sciences·Luis O Soto-RojasJosé Luna-Muñoz

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Methods Mentioned

BETA
Assay
Enzyme-Linked Immunosorbent Assay
electrophoresis
X-ray
ELISA

Software Mentioned

ImageJ
EZQuant
EZ Quant - Gel

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