Microglial depletion disrupts normal functional development of adult-born neurons in the olfactory bulb.

ELife
Jenelle WallaceVenkatesh N Murthy

Abstract

Microglia play key roles in regulating synapse development and refinement in the developing brain, but it is unknown whether they are similarly involved during adult neurogenesis. By transiently depleting microglia from the healthy adult mouse brain, we show that microglia are necessary for the normal functional development of adult-born granule cells (abGCs) in the olfactory bulb. Microglial depletion reduces the odor responses of developing, but not preexisting GCs in vivo in both awake and anesthetized mice. Microglia preferentially target their motile processes to interact with mushroom spines on abGCs, and when microglia are absent, abGCs develop smaller spines and receive weaker excitatory synaptic inputs. These results suggest that microglia promote the development of excitatory synapses onto developing abGCs, which may impact the function of these cells in the olfactory circuit.

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Citations

Aug 7, 2020·Developmental Neurobiology·Sebastiaan De SchepperSoyon Hong
Aug 28, 2020·Frontiers in Neuroscience·Sarah MalvautArmen Saghatelyan
Oct 30, 2020·Frontiers in Immunology·Elisa Eme-Scolan, Samantha J Dando
Feb 9, 2021·Frontiers in Cellular Neuroscience·Sana ChintamenSteven G Kernie
Feb 15, 2021·Developmental Neurobiology·Megumi Andoh, Ryuta Koyama
Jun 8, 2021·Neurochemistry International·Tingting Zheng, Zhengxiang Zhang
May 18, 2021·Frontiers in Cell and Developmental Biology·Milena TucićPavle Andjus
Jul 16, 2021·Frontiers in Molecular Neuroscience·Kate BeecherSelena E Bartlett
Aug 21, 2021·Cellular & Molecular Immunology·Joshua D CrapserKim N Green
Oct 14, 2021·Immunity·Katharina BorstMarco Prinz

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