Microglial expression of chemokine receptor CCR5 during rat forebrain development and after perinatal hypoxia-ischemia

Journal of Neuroimmunology
Rita M CowellF S Silverstein

Abstract

The chemokine macrophage inflammatory protein 1alpha (CCL3) is expressed by immune cells in the normal and injured perinatal brain. To determine whether the chemokine receptor CCR5 is a relevant target for CCL3 in the brain, we used RT-PCR and immunocytochemistry to assess changes in CCR5 expression and localization in developing normal and injured rat forebrain. CCR5 protein was expressed predominately by resting and activated microglia until 2 weeks of age. Neonatal hypoxia-ischemia increased CCR5 mRNA expression while causing CCR5 internalization, indicating receptor activation. These data implicate CCR5 in microglial recruitment and activation during brain development and after neonatal brain injury.

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Citations

Apr 1, 2009·Molecular and Cellular Neurosciences·Renee J GordonBronwen Connor
Dec 21, 2011·Journal of Neurochemistry·Jaclyn M SchwarzStaci D Bilbo
Dec 18, 2013·Annals of Neurology·Hayde BolouriCarina Mallard
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Sep 18, 2012·Frontiers in Neuroendocrinology·Staci D Bilbo, Jaclyn M Schwarz
Apr 30, 2011·Physiological Reviews·Helmut KettenmannAlexei Verkhratsky
Dec 17, 2018·Molecular Neurobiology·Daniel YoungerNamas Chandra
Aug 27, 2019·Frontiers in Aging Neuroscience·Tianwen Li, Jianhong Zhu

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