Microglial expression of prostaglandin EP3 receptor in excitotoxic lesions in the rat striatum

Neurochemistry International
Helen SlawikM Hüll

Abstract

Prostaglandins (PG) are produced by the enzymatic activity of cyclooxygenase (COX). PGs and COX have been implicated in the pathophysiology of excitotoxicity and neurodegeneration in the central nervous system (CNS). The PGE2 receptor EP3 is the most abundantly expressed PGE2 receptor subtype in the brain. So far, in the innate rat brain EP3 receptors have been found exclusively in neurons. The aim of this study was to investigate whether EP3 expression in the brain changes under neurodegenerative circumstances such as an acute excitotoxic lesion. Intrastriatal injection of quinolinic acid (QUIN) resulted in a loss of EP3-positive striatal neurons, while simultaneously small glial-shaped EP3-positive cells appeared. Five days after lesioning, 63% of the glial-shaped EP3-positive cells could be identified as ED-1 expressing microglial cells. This percentage increased to 82% after 10 days, suggesting that most of the EP3-positive ED-1-negative cells on day 5 may be microglia which did not yet express ED-1. ED-1-positive microglia also expressed COX-1. These experiments show for the first time that activated microglial cells in excitotoxic lesions express in vivo the PGE2 receptor EP3 and the PGE2 synthesizing enzyme COX-1. Activa...Continue Reading

References

Nov 1, 1992·Archives of Biochemistry and Biophysics·H IschiropoulosJ S Beckman
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S MoncadaR M Palmer
Jun 1, 1990·Biochemical Medicine and Metabolic Biology·G H RaoJ G White
Jun 1, 1986·British Journal of Pharmacology·H AzumaS Sekizaki
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·L J IgnarroM S Wolin
Oct 1, 1995·Free Radical Biology & Medicine·S Goldstein, G Czapski
Jan 1, 1993·Seminars in Thrombosis and Hemostasis·E TremoliG Di Minno
Feb 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·M A MoroS Moncada
May 1, 1996·Journal of Vascular Research·R Busse, I Fleming
Feb 11, 1997·Biochemistry·A FriebeD Koesling
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·A DenicolaR Radi
Aug 28, 1998·Naunyn-Schmiedeberg's Archives of Pharmacology·D Koesling
Apr 20, 1999·The Journal of Experimental Medicine·S MassbergF Hofmann
Jul 23, 1999·Archives of Biochemistry and Biophysics·N RomeroR Radi
Nov 11, 1999·British Journal of Pharmacology·M B HussainR J MacAllister
Dec 22, 1999·Journal of Cardiovascular Pharmacology·L J IgnarroC Napoli
Jan 1, 2000·Cardiovascular Research·R S RonsonJ Vinten-Johansen
Nov 23, 2000·Biochemistry·R F KhairutdinovJ K Hurst
Dec 1, 2001·Free Radical Biology & Medicine·M WeberG Kojda
Jul 26, 2003·Circulation Research·Andreas Friebe, Doris Koesling
Sep 11, 2003·FEBS Letters·Thorsten KoberGeorg Kojda

❮ Previous
Next ❯

Citations

Jan 13, 2010·Journal of Neuroinflammation·Johannes C M SchlachetzkiMichael Hüll
Nov 15, 2011·Pharmacology & Therapeutics·Noboru Toda
May 14, 2008·Experimental Gerontology·Christian Lange-Asschenfeldt, Georg Kojda
Jul 1, 2008·British Journal of Pharmacology·M OppermannG Kojda
Feb 24, 2006·Pediatric Diabetes·Christina Mylona-KarayanniElli F Kamper
Jul 23, 2013·European Journal of Pharmacology·Noboru TodaTomio Okamura
Mar 15, 2016·Antioxidants & Redox Signaling·Iraida G Sharina, Emil Martin
Aug 18, 2016·Journal of Pharmacological Sciences·Noboru Toda, Tomio Okamura
Apr 29, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Ming ZhangShui-Ping Zhao
Jan 21, 2006·Journal of Cardiovascular Pharmacology·Shao-cai HongZhi-hong Wu
Dec 15, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Xiaoning HanJian Wang
Jun 2, 2016·Journal of Neurochemistry·Katrin I AndreassonLinda J Van Eldik
Jul 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Myung-Soon YangEunhye Joe
Jul 11, 2012·Mediators of Inflammation·Isabel Vieira de Assis LimaAntonio Carlos Pinheiro de Oliveira
Apr 17, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Jenna L LeclercSylvain Doré
Jun 6, 2018·Journal of Alzheimer's Disease : JAD·Paul Edison, David J Brooks
Jul 1, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Akihiko HiyamaJoji Mochida
Jul 22, 2019·International Journal of Environmental Research and Public Health·Roger G Biringer
Sep 7, 2006·Neuro-degenerative Diseases·Lisette ArnaudMaria E Figueiredo-Pereira
Jan 27, 2010·Neuroscience Bulletin·Li-Li WeiWei Chen
Nov 26, 2008·Journal of Leukocyte Biology·Bart R TambuyzerEtienne J Nouwen
Jul 16, 2010·Journal of Neural Transmission·Michael T HenekaMarkus Peter Kummer
May 12, 2009·Neurochemistry International·Anthony J HutchinsonJohn W Regan
Feb 11, 2009·Journal of Neuroimmunology·Sofiyan SaleemSylvain Doré
Dec 1, 2009·Brain Research Reviews·Michael T HenekaAlexei Verkhratsky

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Alzheimer's Disease: Microglia

Microglia are a type of glial cell found throughout the brain and spinal cord. Microglia have been found to be associated with Alzheimer's disease development and progression. Here are the latest discoveries pertaining to Alzheimer's disease and microglia.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.