Microglial markers in the frontal cortex are related to cognitive dysfunctions in major depressive disorder

Journal of Affective Disorders
Hua LiSzabolcs Kéri

Abstract

Evidence suggests that microglia-mediated processes are implicated in the pathophysiology of major depressive disorder (MDD). The relationship between these processes and cognitive dysfunctions has not been explored. We recruited 50 never-medicated patients with MDD and 30 healthy control subjects. We used [18F]-FEPPA positron emission tomography (PET) to examine translocator protein total distribution volume (TSPO VT), a marker of microglia. Cognitive functions were evaluated with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) (attention, immediate and delyed memory, language, and visuospatial functions). Patients with MDD showed elevated TSPO VT in all regions of interest (white matter, grey matter, frontal cortex, temporal cortex, and hippocampus) and were impaired on the attention and delayed memory domains of the RBANS. In the frontal cortex, increased TSPO VT was associated with lower scores on the RBANS attention domain when the analysis was corrected for age, gender, education, and depressive symptoms. Affective functions were not investigated, the specificity of [18F]-FEPPA binding is limited, TSPO may reflect microglia/macrophage density rather than activation, and the sample was not ba...Continue Reading

Citations

May 30, 2020·International Journal of Molecular Sciences·Stefanie Hoffmann, Cordian Beyer
Oct 31, 2020·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Ather Muneer
Dec 24, 2018·Journal of Affective Disorders·Rebecca StrawbridgeAnthony J Cleare
Mar 24, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Zixuan CaiChao Huang
Mar 2, 2021·Acta Pharmaceutica Sinica. B·Lingling ZhangSteven H Liang
Mar 19, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Livia J De Picker, Benno C M Haarman
Apr 27, 2021·Indian Journal of Psychiatry·Jing YangJing Liu
Sep 6, 2020·CNS & Neurological Disorders Drug Targets·Sadayuki Hashioka
Aug 14, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Fabien ChauveauHervé Boutin

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